Frontotemporal lobar degeneration (FTLD) comprises two main classes of
neurodegenerative diseases characterized by neuronal/glial proteinaceous inclusions (ie …

Background Frontotemporal dementia (FTD) is predominantly a presenile disorder that is
characterised by behavioural changes and cognitive impairment, particularly in language …

The aim of this study was to improve the neuropathologic recognition and provide criteria for
the pathological diagnosis in the neurodegenerative diseases grouped as frontotemporal …

TAR DNA-binding protein 43 (TDP-43) is a major pathological protein of sporadic and
familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions …

Frontotemporal dementia (FTD), characterized by behavioural and language disorders, is a
clinically, genetically and pathologically heterogeneous group of diseases. The most …

Mutations in the progranulin gene (GRN) are a major cause of frontotemporal lobar
degeneration with ubiquitin-positive, tau-negative inclusions (FTLD-U) but the distinguishing …

Background Mutation in the progranulin gene (GRN) can cause frontotemporal dementia
(FTD). However, it is unclear whether some rare FTD-relatedGRNvariants are pathogenic …

Cancer and Alzheimer's disease (AD) are two common disorders for which the final
pathophysiological mechanism is not yet clearly defined. In a prospective longitudinal study …

Background To date, there have been no reports of individuals who have been
characterized longitudinally using clinical and cognitive measures and who transitioned …

Progressive nonfluent aphasia (PNFA) is a clinical syndrome characterized by motor speech
impairment and agrammatism, with relative sparing of single word comprehension and …