Microbial biomanufacturing, powered by the advances of synthetic biology, has attracted
growing interest for the production of diverse products. In contrast to conventional microbes …

Metabolic engineering involves the engineering and optimization of processes from single-
cell to fermentation in order to increase production of valuable chemicals for health, food …

Abstract Design of de novo synthetic regulatory DNA is a promising avenue to control gene
expression in biotechnology and medicine. Using mutagenesis typically requires screening …

Efficient genome engineering is critical to understand and use microbial functions. Despite
recent development of tools such as CRISPR-Cas gene editing, efficient integration of …

Pseudomonas putida is evolutionarily endowed with features relevant for bioproduction,
especially under harsh operating conditions. The rich metabolic versatility of this species …

Functional metagenomics is a powerful experimental tool to identify antibiotic resistance
genes (ARGs) in the environment, but the range of suitable host bacterial species is limited …

The arms race between (bacterio) phages and their hosts is a recognised hot spot for
genome evolution. Indeed, phages and their components have historically paved the way for …

The widespread Pseudomonas genus comprises a collection of related species with
remarkable abilities to degrade plastics and polluted wastes and to produce a broad set of …

Prevention is better than cure. A milestone of the anthropocene is the emergence of a series
of epidemics and pandemics often characterized by the transmission of a pathogen from …

Phages have certain features, such as their ability to form protein–protein interactions, that
make them good candidates for use in a variety of beneficial applications, such as in human …