The largest surface of the human body exposed to the external environment is the gut. At this
level, the intestinal barrier includes luminal microbes, the mucin layer, gastrointestinal …

Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease whose incidence has
risen worldwide in recent years. Accumulating evidence shows that oxidative stress plays an …

Metabolite alteration has been associated with the pathogenesis of inflammatory bowel
disease (IBD), including colitis. Mannose, a natural bioactive monosaccharide that is …

While gut microbiome and host gene regulation independently contribute to gastrointestinal
disorders, it is unclear how the two may interact to influence host pathophysiology. Here we …

The importance of gut microbiota in human health and pathophysiology is undisputable.
Despite the abundance of metagenomics data, the functional dynamics of gut microbiota in …

Reactive oxygen species (ROS) molecules are implicated in signal transduction pathways
and thereby control a range of biological activities. Immune cells are constantly confronted …

Inflammatory bowel diseases are common, complex, immune-mediated conditions with a
sharply rising global prevalence. While major advances since 2000 have provided strong …

Oxidative stress is a major contributor to the pathogenesis of various human diseases as
well as to the aging process. Mitochondria, as the center of cellular metabolism and major …

The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide and
parallels comorbidities such as obesity, metabolic syndrome, dyslipidemia, and diabetes …

Background Neurodegenerative diseases are debilitating conditions that diminish the
quality of life and pose significant financial and social burdens. Therefore, strategies to …