Extracellular vesicles (EVs) carry diverse bioactive components including nucleic acids,
proteins, lipids and metabolites that play versatile roles in intercellular and interorgan …

With the increase of population aging, the number of Alzheimer's disease (AD) patients is
also increasing. According to current estimates, approximately 11% of people over 65 suffer …

Systemic messenger RNA (mRNA) delivery to organs outside the liver, spleen, and lungs
remains challenging. To overcome this issue, we hypothesized that altering nanoparticle …

The extracellular vesicle (EV) surface proteome (surfaceome) acts as a fundamental
signalling gateway by bridging intra‐and extracellular signalling networks, dictates EVs' …

Extracellular vesicles (EVs) function as a mode of intercellular communication and
molecular transfer to elicit diverse biological/functional response. Accumulating evidence …

The native role of extracellular vesicles (EVs) in mediating the transfer of biomolecules
between cells has raised the possibility to use them as therapeutic vehicles. The …

Therapeutic benefits of mesenchymal stem cells (MSCs) are now widely believed to come
from their paracrine signalling, ie secreted factors such as cytokines, chemokines, and …

Bone marrow mesenchymal stromal cell-derived exosomes (BMSC-Exos) can recruit stem
cells for bone repair, with neovessels serving as the main migratory channel for stem cells to …

Pancreatic cancer (PC) is a devastating disease, offering poor mortality rates for patients.
The current challenge being faced is the inability to diagnose patients in a timely manner …

The tumor microenvironment (TME) includes a network of cancerous and non-cancerous
cells, together with associated blood vessels, the extracellular matrix, and signaling …