Polyamines are polycations that interact with negatively charged molecules such as DNA,
RNA and proteins. They play multiple roles in cell growth, survival and proliferation …

Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways
is often the result of genetic alterations in critical components in these pathways or upstream …

To investigate miRNA function in human acute myeloid leukemia (AML) stem cells (LSC), we
generated a prognostic LSC-associated miRNA signature derived from functionally …

Abstract The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by
genetic alterations in upstream signaling molecules such as receptor tyrosine kinases …

The global burden of cancer is growing and a wide disparity in the incidence, malignancy
and mortality of different types of cancer between each sex has been demonstrated. The sex …

Hematopoiesis, the process by which the hematopoietic stem cells and progenitors
differentiate into blood cells of various lineages, involves complex interactions of …

Neurodegenerative diseases (NDs) are common chronic diseases related to progressive
damage of the nervous system. Globally, the number of people with an ND is dramatically …

Aberrant activation of signal transduction pathways can transform a normal cell to a
malignant one and can impart survival properties that render cancer cells resistant to …

Glioblastoma multiforme (GBM) is one of the most frequently occurring tumors in the central
nervous system and the most malignant tumor among gliomas. Despite aggressive …

It has become apparent that regulation of protein translation is an important determinant in
controlling cell growth and leukemic transformation. The phosphoinositide 3-kinase …