Oxidative stress in human pathology and aging: molecular mechanisms and perspectives
Reactive oxygen and nitrogen species (RONS) are generated through various endogenous
and exogenous processes; however, they are neutralized by enzymatic and non-enzymatic …
and exogenous processes; however, they are neutralized by enzymatic and non-enzymatic …
[HTML][HTML] The role of oxidative stress in neurodegenerative diseases
Oxidative stress is induced by an imbalanced redox states, involving either excessive
generation of reactive oxygen species (ROS) or dysfunction of the antioxidant system. The …
generation of reactive oxygen species (ROS) or dysfunction of the antioxidant system. The …
Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration
Iron dysregulation has been implicated in multiple neurodegenerative diseases, including
Parkinson's disease (PD). Iron-loaded microglia are frequently found in affected brain …
Parkinson's disease (PD). Iron-loaded microglia are frequently found in affected brain …
Emerging therapies in Parkinson disease—repurposed drugs and new approaches
Parkinson disease (PD) treatment options have conventionally focused on dopamine
replacement and provision of symptomatic relief. Current treatments cause undesirable …
replacement and provision of symptomatic relief. Current treatments cause undesirable …
Quantitative susceptibility mapping (QSM): decoding MRI data for a tissue magnetic biomarker
In MRI, the main magnetic field polarizes the electron cloud of a molecule, generating a
chemical shift for observer protons within the molecule and a magnetic susceptibility …
chemical shift for observer protons within the molecule and a magnetic susceptibility …
[HTML][HTML] Interactions of dopamine, iron, and alpha-synuclein linked to dopaminergic neuron vulnerability in Parkinson's disease and Neurodegeneration with Brain …
RM Wise, A Wagener, UM Fietzek, T Klopstock… - Neurobiology of …, 2022 - Elsevier
Dopamine metabolism, alpha-synuclein pathology, and iron homeostasis have all been
implicated as potential contributors to the unique vulnerability of substantia nigra …
implicated as potential contributors to the unique vulnerability of substantia nigra …
Association between heavy metal exposure and Parkinson's disease: a review of the mechanisms related to oxidative stress
Parkinson's disease (PD) is a gradually progressing neurodegenerative condition that is
marked by a loss of motor coordination along with non-motor features. Although the precise …
marked by a loss of motor coordination along with non-motor features. Although the precise …
Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson's disease
Parkinson's disease (PD) is associated with increased iron levels in the substantia nigra
(SNc). This study evaluated whether the iron chelator, deferiprone, is well tolerated, able to …
(SNc). This study evaluated whether the iron chelator, deferiprone, is well tolerated, able to …
Biological metals and metal-targeting compounds in major neurodegenerative diseases
KJ Barnham, AI Bush - Chemical Society Reviews, 2014 - pubs.rsc.org
Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …
Cerebral iron deposition in neurodegeneration
Disruption of cerebral iron regulation appears to have a role in aging and in the
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …