Frailty is a clinical syndrome characterized by a reduced physiologic reserve, increased
vulnerability to stressors and an increased risk of adverse outcomes. People with atrial …

Atrial fibrillation (AF) and venous thromboembolism (VTE) are highly prevalent conditions
with a significant healthcare burden, and represent the main indications for anticoagulation …

Background Clinical complexity is common in atrial fibrillation (AF) patients. We assessed
the impact of clinical complexity on oral anticoagulant (OAC) treatment patterns and major …

Stroke prevention in patients with atrial fibrillation (AF) is one pillar of the management of
this common arrhythmia. Substantial advances in the epidemiology and associated …

Background Frailty is a medical syndrome characterised by reduced physiological reserve
and increased vulnerability to stressors. Data regarding the relationship between frailty and …

Background Polypharmacy may affect outcomes in patients with atrial fibrillation (AF) using
non-vitamin K antagonist oral anticoagulants (NOACs) or vitamin K antagonists (VKAs) due …

Aims The clinical relevance of common pharmacokinetic interactions with non-vitamin K
antagonist oral anticoagulants (NOACs) often remains unclear. Therefore, the impact of P …

Apixaban and rivaroxaban are the two most prescribed direct factor Xa inhibitors. With the
increased use of DOACs in real-world settings, safety and efficacy concerns have emerged …

Background Atrial fibrillation (AF) is associated with cognitive decline, with anticoagulated
subjects potentially having a reduced risk compared with non-anticoagulated subjects …

Aims Data on non-vitamin K antagonist oral anticoagulants (NOACs) use in patients with
atrial fibrillation (AF) and frailty are scarce. Therefore, the impact of frailty on AF-related …