The development and application of traditional drugs represented by small molecule
chemical drugs and biological agents, especially inhibitors, have become the mainstream …

The interleukin-1 receptor associated kinase 4 (IRAK-4) is a member of serine-threonine
kinase family, which plays an important role in the regulation of interleukin-1 receptors (IL …

We report small molecular PROTAC compounds targeting the androgen receptor N-terminal
domain (AR-NTD), which were obtained by tethering AR-NTD antagonists and different …

Ferroptosis is an iron-dependent, non-apoptotic form of cell death involving in various
disease processes. Mechanistically, glutathione peroxidase 4 (GPX4) which belongs to the …

Parkinson's disease (PD) is a multifactorial disease due to a complex interplay between
genetic and epigenetic factors. Recent efforts shed new light on the epigenetic mechanisms …

Targeted protein degradation (TPD) technology is based on a unique pharmacological
mechanism that has profoundly revolutionized medicinal research by overcoming limitations …

The processes used by academic and industrial scientists to discover new drugs have
recently experienced a true renaissance, with many new and exciting techniques being …

Epidermal growth factor receptor (EGFR) is an oncogenic drug target and plays a critical role
in several cellular functions including cancer cell growth, survival, proliferation …

Alzheimer's disease (AD) as the most prevalent dementia type has become one of the
greatest threats to the health and life of the elder people worldwide. Although there has …

Targeted protein degradation using proteolysis-targeting chimeras (PROTACs) has
emerged as an effective strategy for drug discovery, given their unique advantages over …