Brassica vegetables are common components of the diet and have beneficial as well as
potentially adverse health effects. Following enzymatic breakdown, some glucosinolates in …

For many decades, the use of synthetic chemicals as drugs has been effective in the
treatment of most diseases. Moreover, from ancient to modern history, many traditional plant …

Delayed-release dimethyl fumarate (also known as gastro-resistant dimethyl fumarate), an
oral therapeutic containing dimethyl fumarate (DMF) as the active ingredient, is currently …

Chronic kidney disease (CKD) is featured by a progressive decline of kidney function and is
mainly caused by chronic diseases such as diabetes mellitus and hypertension. CKD is a …

Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor that controls cellular
defense responses against toxic and oxidative stress by modulating the expression of genes …

Cruciferous vegetables are widely acknowledged to provide chemopreventive benefits in
humans, but they are not generally consumed at levels that effect significant change in …

The pathogenic processes involving in the development of diabetes range from autoimmune
destruction of pancreatic β-cells with consequent insulin deficiency to abnormalities that …

Although moderate physical exercise is considered an essential component of a healthy
lifestyle that leads the organism to adapt itself to different stresses, exercise, especially when …

Cardiotoxicity is one of the major side effects encountered during cancer chemotherapy with
doxorubicin (DOX) and other anthracyclines. Previous studies have shown that oxidative …

The pregnane X receptor (PXR) is a kind of orphan nuclear receptor activated by a series of
ligands. Environmental endocrine disruptors (EEDs) are a wide class of molecules present …