Sulforaphane prevents doxorubicin-induced oxidative stress and cell death in rat H9c2 cells

B Li, DS Kim, RK Yadav… - … journal of molecular …, 2015 - spandidos-publications.com
Sulforaphane, a natural isothiocyanate compound found in cruciferous vegetables, has
been shown to exert cardioprotective effects during ischemic heart injury. However, the …

Anticancer properties of sulforaphane: current insights at the molecular level

M Asif Ali, N Khan, N Kaleem, W Ahmad… - Frontiers in …, 2023 - frontiersin.org
Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications.
Sulforaphane can be extracted from the plants of the genus Brassica. However, broccoli …

Sulforaphane as an inducer of glutathione prevents oxidative stress‐induced cell death in a dopaminergic‐like neuroblastoma cell line

A Tarozzi, F Morroni, A Merlicco, S Hrelia… - Journal of …, 2009 - Wiley Online Library
The total GSH depletion observed in the substantia nigra (SN) appears to be responsible for
subsequent oxidative stress (OS), mitochondrial dysfunction, and dopaminergic cell loss in …

Sulforaphane protects against cisplatin-induced nephrotoxicity

CE Guerrero-Beltrán, M Calderón-Oliver, E Tapia… - Toxicology letters, 2010 - Elsevier
Cisplatin (cis-diamminedichloroplatinum II, CDDP) is a chemotherapeutic agent that induces
nephrotoxicity associated with oxidative/nitrosative stress. Sulforaphane (SFN) is an …

[图书][B] Xenobiotic metabolic enzymes: bioactivation and antioxidant defense

CH Chen - 2020 - Springer
Xenobiotics are commonly referred to as foreign compounds that humans digest or inhale
and are not produced by the body, such as foods, drugs, other chemicals, and air pollutants …

Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli

D James, S Devaraj, P Bellur, S Lakkanna… - Nutrition …, 2012 - academic.oup.com
Consumption of broccoli has long been considered to play a role in a healthy diet. Broccoli
accumulates significant amounts of the phytonutrient glucoraphanin (4-methylsulfinylbutyl …

Neuroprotective effects of sulforaphane on cholinergic neurons in mice with Alzheimer's disease-like lesions

R Zhang, J Zhang, L Fang, X Li, Y Zhao, W Shi… - International Journal of …, 2014 - mdpi.com
Alzheimer's disease (AD) is a common neurodegenerative disease in elderly individuals,
and effective therapies are unavailable. This study was designed to investigate the …

Extracellular matrix remodeling and modulation of inflammation and oxidative stress by sulforaphane in experimental diabetic peripheral neuropathy

PE Moustafa, NF Abdelkader, SA El Awdan… - Inflammation, 2018 - Springer
The peripheral nervous system is one of many organ systems that can be profoundly
impacted in diabetes mellitus. Diabetic peripheral neuropathy has a significant negative …

Potential Chemopreventive Agents Based on the Structure of the Lead Compound 2-Bromo-1-hydroxyphenazine, Isolated from Streptomyces Species, Strain …

M Conda-Sheridan, L Marler, EJ Park… - Journal of medicinal …, 2010 - ACS Publications
The isolation of 2-bromo-1-hydroxyphenazine from a marine Streptomyces species, strain
CNS284, and its activity against NF-κB, suggested that a short and flexible route for the …

Arbutin attenuates isoproterenol-induced cardiac hypertrophy by inhibiting TLR-4/NF-κB pathway in mice

N Nalban, R Sangaraju, S Alavala, SM Mir… - Cardiovascular …, 2020 - Springer
Arbutin is a glycoside reported for its anti-oxidant, anti-inflammatory and anti-tumor
properties. However, the cardioprotective effect of Arbutin is not well established. The study …