Aim: Sulforaphane (SFN), a natural dietary isothiocyanate, is found to exert beneficial effects
for cardiovascular diseases. This study aimed to investigate the mechanisms underlying the …

Oxidative stress promotes Ca 2+-dependent opening of the mitochondrial inner membrane
permeability transition pore (PTP), causing bioenergetic failure and subsequent cell death in …

Sulforaphane, a Natural Isothiocyanate Compound, Improves Cardiac Function and
Remodeling by Inhibiting Oxidative Stress and Inflammation in a Rabbit Model of Chronic Heart …

Aims Preventive and/or therapeutic interventions using natural products for ischemic heart
disease have gained considerable attention worldwide. This study investigated the …

Sulforaphane is a new and effective anti-cancer component that is abundant in broccoli. In
the past few years, the patterns of variability in glucosinolate content and its regulation in A …

This work was designed to further study the mechanism by which sulforaphane (SFN) exerts
a renoprotective effect against cisplatin (CIS)-induced damage. It was evaluated whether …

Results: Acrolein showed a significant (p< 0.001) increase in the levels of oxidative stress
parameters and down-regulated Nrf-2 expression. Acrolein-induced inflammation was …

Background Electrophilic xenobiotics and endogenous products from oxidative stresses
induce the glutathione S-transferases (GSTs), which form a large family within the phase II …

The purpose of this study was the development of multifunctional liposomes for nasal
administration of tacrine hydrochloride. Liposomes were prepared using traditional …

The isothiocyanate sulforaphane (SF), abundant in Cruciferous vegetables, is known to
induce antioxidant/detoxification enzymes in many cancer cell lines, but studies focused on …