Sulforaphane preconditioning sensitizes human colon cancer cells towards the bioreductive anticancer prodrug PR-104A

MM Erzinger, C Bovet, KM Hecht, S Senger, P Winiker… - PLoS …, 2016 - journals.plos.org
The chemoprotective properties of sulforaphane (SF), derived from cruciferous vegetables,
are widely acknowledged to arise from its potent induction of xenobiotic-metabolizing and …

Sulforaphane induces apoptosis in rhabdomyosarcoma and restores TRAIL-sensitivity in the aggressive alveolar subtype leading to tumor elimination in mice

E Bergantin, C Quarta, C Nanni, S Fanti… - Cancer Biology & …, 2014 - Taylor & Francis
Rhadbomyosarcoma (RMS) is the most common soft-tissue sarcoma in children and is
subdivided in the embryonal (ERMS) and alveolar (ARMS) subtypes, the latter being …

Dual roles of sulforaphane in cancer treatment

T Xu, D Ren, X Sun, G Yang - Anti-Cancer Agents in Medicinal …, 2012 - ingentaconnect.com
Sulforaphane (SFN), one of naturally occurring isothiocyanates (ITCs), has huge cancer
chemopreventive potential. It modulates cell death, cell cycle, angiogenesis, susceptibility to …

Effect of broccoli extract enriched diet on liver cholesterol oxidation in rats subjected to exhaustive exercise

V Cardenia, MT Rodriguez-Estrada, A Lorenzini… - The Journal of Steroid …, 2017 - Elsevier
The effect of broccoli extract (BE)-enriched diet was studied in order to evaluate its ability to
counteract liver cholesterol oxidation products (COPs) induced by acute strenuous exercise …

Assessment of DNA damage and repair in adults consuming allyl isothiocyanate or Brassica vegetables

CS Charron, BA Clevidence, GA Albaugh… - The Journal of nutritional …, 2013 - Elsevier
Allyl isothiocyanate (AITC) is a dietary component with possible anticancer effects, though
much information about AITC and cancer has been obtained from cell studies. To investigate …

NAD (P) H: quinone oxidoreductase 1 activity reduces hypertrophy in 3T3-L1 adipocytes

EE Vomhof-DeKrey, MJ Picklo - Free Radical Biology and Medicine, 2012 - Elsevier
The nuclear factor E2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1)
pathway responds to oxidative stress via control of several antioxidant defense gene …

Sulforaphane protected the injury of human vascular endothelial cell induced by LPC through up-regulating endogenous antioxidants and phase II enzymes

B Li, S Tian, X Liu, C He, Z Ding, Y Shan - Food & function, 2015 - pubs.rsc.org
Sulforaphane (SFN), which is an isothiocyanate (ITC) that is found in cruciferous vegetables,
has received considerable attention because of its beneficial effects. In this study, the …

Protection of retinal function by sulforaphane following retinal ischemic injury

LA Ambrecht, JI Perlman, JF McDonnell, Y Zhai… - Experimental Eye …, 2015 - Elsevier
Sulforaphane, a precursor of glucosinolate in cruciferous vegetables such as broccoli and
cauliflower, has been shown to protect brain ischemic injury. In this study, we examined the …

Synthesis and structure–activity relationships of tetrahydro-β-carboline derivatives as anticancer and cancer-chemopreventive agents

M Zhang, EJ Park, TP Kondratyuk… - Anticancer …, 2018 - ar.iiarjournals.org
Background/Aim: There is an unmet clinical need to develop new anticancer and
chemopreventive agents. The aim of the present study was to identify β-carboline derivatives …

Modulation of xenobiotic metabolism in ginger (Zingiber officinale Roscoe) fed rats

K Nirmala, TP Krishna, K Polasa - International Journal of …, 2013 - info.submit4journal.com
An association between diet and cancer has been documented only in recent decades.
Biotransformation enzymes play an important role in the metabolism of xenobiotics that may …