[HTML][HTML] Dopamine receptors and neurodegeneration
Dopamine (DA) is one of the major neurotransmitters and participates in a number of
functions such as motor coordination, emotions, memory, reward mechanism …
functions such as motor coordination, emotions, memory, reward mechanism …
Dopamine D3 receptor as a new pharmacological target for the treatment of depression
A substantial proportion of depressed patients do not respond to current antidepressant drug
therapies. So far, antidepressant drugs have been developed based on the “monoaminergic …
therapies. So far, antidepressant drugs have been developed based on the “monoaminergic …
Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs
JD McCorvy, KV Butler, B Kelly, K Rechsteiner… - Nature chemical …, 2018 - nature.com
Abstract Development of biased ligands targeting G protein-coupled receptors (GPCRs) is a
promising approach for current drug discovery. Although structure-based drug design of …
promising approach for current drug discovery. Although structure-based drug design of …
Current drug treatments targeting dopamine D3 receptor
Dopamine receptors (DR) have been extensively studied, but only in recent years they
became object of investigation to elucidate the specific role of different subtypes (D1R, D2R …
became object of investigation to elucidate the specific role of different subtypes (D1R, D2R …
Advances and challenges in the search for D2 and D3 dopamine receptor-selective compounds
Compounds that target D2-like dopamine receptors (DRs) are currently used as therapeutics
for several neuropsychiatric disorders including schizophrenia (antagonists) and …
for several neuropsychiatric disorders including schizophrenia (antagonists) and …
Functionally Selective Dopamine D2, D3 Receptor Partial Agonists
D Möller, RC Kling, M Skultety, K Leuner… - Journal of medicinal …, 2014 - ACS Publications
Dopamine D2 receptor-promoted activation of Gαo over Gαi may increase synaptic plasticity
and thereby might improve negative symptoms of schizophrenia. Heterocyclic dopamine …
and thereby might improve negative symptoms of schizophrenia. Heterocyclic dopamine …
Targeting the dopamine D3 receptor: an overview of drug design strategies
A Cortes, E Moreno, M Rodriguez-Ruiz… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Dopamine is a neurotransmitter widely distributed in both the periphery and the
central nervous system (CNS). Its physiological effects are mediated by five closely related G …
central nervous system (CNS). Its physiological effects are mediated by five closely related G …
Dopamine D3 and 5-HT1B receptor dysregulation as a result of psychostimulant intake and forced abstinence: Implications for medications development
Addiction to psychostimulants, including cocaine and amphetamine, is associated with
dysregulation of dopamine and serotonin (5-HT) neurotransmitter systems …
dysregulation of dopamine and serotonin (5-HT) neurotransmitter systems …
Antipsychotic haloperidol binding to the human dopamine D3 receptor: Beyond docking through QM/MM refinement toward the design of improved schizophrenia …
As the dopamine D3R receptor is a promising target for schizophrenia treatment, an
improved understanding of the binding of existing antipsychotics to this receptor is crucial for …
improved understanding of the binding of existing antipsychotics to this receptor is crucial for …
Design, synthesis, and structure–activity relationship studies of a series of [4-(4-carboxamidobutyl)]-1-arylpiperazines: Insights into structural features contributing to …
S Ananthan, SK Saini, G Zhou, JV Hobrath… - Journal of medicinal …, 2014 - ACS Publications
Antagonist and partial agonist modulators of the dopamine D3 receptor (D3R) have
emerged as promising therapeutics for the treatment of substance abuse and …
emerged as promising therapeutics for the treatment of substance abuse and …