Gene editing is the specific modification of genome sequences at desired sites using
technologies derived from zinc finger nucleases (ZFNs), transcription activator-like effector …

At present, there are many strategies to improve the activity of CRISPR/Cas9. A well-known
and effective approach is guide RNA modification. Many chemical guide RNA modifications …

摘要针对CRISPR/Cas9 系统在DNA, RNA 和蛋白3 种水平的递送形式, 本文着重介绍了
CRISPR/Cas9 系统的病毒载体和非病毒载体的研究现状和CRISPR/Cas9 系统递送的新策略 …

Acinetobacter baumannii is widely recognized as a human opportunistic pathogen in
nosocomial infections. The proliferation of multidrug-resistant strains of A. baumannii has …

Campylobacter jejuni is the leading foodborne bacterial pathogen that causes human
gastroenteritis worldwide linked to the consumption of undercooked broiler livers …

Staphylococcus aureus is one of the major pathogens responsible for causing food
poisoning worldwide. The emergence of antibiotic resistance in this bacterium is influenced …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; initially named as 2019-
nCoV) is the cause of the novel coronavirus disease 2019 (COVID-19) pandemic. Its …

Infectious diseases are one of the leading causes of mortality around the world. Among the
various infectious diseases, malaria, HIV, HCV, HBV, tuberculosis and influenza are …

The integration of molecular approaches in medicine allows for a more precise
understanding of the mechanisms underlying infectious diseases, paving the way for …

Pathogens constantly interact with their hosts and the environment, and therefore have
evolved unique virulence mechanisms to target and breach host defense barriers and …