Pancreatic ductal adenocarcinoma (PDAC), already among the deadliest epithelial
malignancies, is rising in both incidence and contribution to overall cancer deaths. Decades …

Cancer has been a leading cause of death for decades. This dismal statistic has increased
efforts to prevent the disease or to detect it early, when treatment is less invasive, relatively …

Overcoming intrinsic resistance to immune checkpoint blockade for microsatellite stable
(MSS) colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC) remains …

Short-read sequencing is the workhorse of cancer genomics yet is thought to miss many
structural variants (SVs), particularly large chromosomal alterations. To characterize missing …

Cancer is driven by genetic change, and the advent of massively parallel sequencing has
enabled systematic documentation of this variation at the whole-genome scale,–. Here we …

Objective Infection by HBV is the main risk factor for hepatocellular carcinoma (HCC)
worldwide. HBV directly drives carcinogenesis through integrations in the human genome …

Distilling biologically meaningful information from cancer genome sequencing data requires
comprehensive identification of somatic alterations using rigorous computational methods …

Metatranscriptomics has revolutionized our ability to explore and understand transcriptional
programs in microbial communities. Moreover, it has enabled us to gain deeper and more …

Accumulating evidence demonstrates that the oral pathobiont Fusobacterium nucleatum is
involved in the progression of an increasing number of tumors types. Thus far, the …

Cancer-microbe associations have been explored for centuries, but cancer-associated fungi
have rarely been examined. Here, we comprehensively characterize the cancer mycobiome …