The impact of cytokines in coronary atherosclerotic plaque: current therapeutic approaches

P Tsioufis, P Theofilis, K Tsioufis… - International Journal of …, 2022 - mdpi.com
Coronary atherosclerosis is a chronic pathological process that involves inflammation
together with endothelial dysfunction and lipoprotein dysregulation. Experimental studies …

Inflammation in myocardial ischemia/reperfusion injury: underlying mechanisms and therapeutic potential

J Francisco, DP Del Re - Antioxidants, 2023 - mdpi.com
Acute myocardial infarction (MI) occurs when blood flow to the myocardium is restricted,
leading to cardiac damage and massive loss of viable cardiomyocytes. Timely restoration of …

IL-6 in the infarcted heart is preferentially formed by fibroblasts and modulated by purinergic signaling

C Alter, AS Henseler, C Owenier… - The Journal of …, 2023 - Am Soc Clin Investig
Plasma IL-6 is elevated after myocardial infarction (MI) and is associated with increased
morbidity and mortality. Which cardiac cell type preferentially contributes to IL-6 expression …

Association of interleukin 6 inhibition with ziltivekimab and the neutrophil-lymphocyte ratio: a secondary analysis of the RESCUE clinical trial

NH Adamstein, JH Cornel, M Davidson, P Libby… - JAMA …, 2023 - jamanetwork.com
Importance The neutrophil-lymphocyte ratio (NLR) independently predicts atherosclerotic
events and is a potential biomarker for residual inflammatory risk. Interleukin (IL) 1β …

Ciprofol attenuates the isoproterenol-induced oxidative damage, inflammatory response and cardiomyocyte apoptosis

Y Yang, Z Xia, C Xu, C Zhai, X Yu, S Li - Frontiers in Pharmacology, 2022 - frontiersin.org
Background and Purpose: Ciprofol (HSK3486), a novel 2, 6-disubstituted phenol derivative,
is a new intravenous anesthetic compound with a similar chemical structure to propofol …

Cardiovascular risk assessment in rheumatoid arthritis: accelerated atherosclerosis, new biomarkers, and the effects of biological therapy

D Popescu, E Rezus, MC Badescu, N Dima… - Life, 2023 - mdpi.com
Rheumatoid arthritis (RA), one of the most common of the chronic inflammatory autoimmune
diseases (CIADs), is recognized as an independent cardiovascular risk factor. Traditional …

[HTML][HTML] Targeting inflammation in atherosclerosis: overview, strategy and directions

R Waksman, I Merdler, BC Case… - …, 2024 - eurointervention.pcronline.com
Atherosclerosis is a chronic condition characterised by the build-up of plaque in the inner
lining of the blood vessels and it is the main underlying cause of cardiovascular disease …

[HTML][HTML] Investigation of the active ingredients of Shuangshen Ningxin Fomula and the mechanism underlying their protective effects against myocardial ischemia …

L Li, L Li, C Cao, F Guo, A Wang, L Lin, Z Liu, H Meng… - Phytomedicine, 2024 - Elsevier
Abstract Background Traditional Chinese medicine, particularly Shuangshen Ningxin
Capsule (SSNX), has been studied intensely. SSNX includes total ginseng saponins (from …

Neutrophil–Lymphocyte Ratio as a Predictor of Cerebral Small Vessel Disease in a Geriatric Community: The I-Lan Longitudinal Aging Study

SY Chuang, YC Hsu, KW Chou, KS Chang, CH Wong… - Brain Sciences, 2023 - mdpi.com
Cerebral Small Vessel Disease (CSVD) frequently affects the elderly, with inflammation
playing a crucial role in related health complications, including dementia, stroke, and SVD …

Identification of hub biomarkers of myocardial infarction by single-cell sequencing, bioinformatics, and machine learning

Q Zhang, Y Guo, B Zhang, H Liu, Y Peng… - Frontiers in …, 2022 - frontiersin.org
Background Myocardial infarction (MI) is one of the first cardiovascular diseases
endangering human health. Inflammatory response plays a significant role in the …