The biology and function of exosomes in cancer

R Kalluri - The Journal of clinical investigation, 2016 - Am Soc Clin Investig
Humans circulate quadrillions of exosomes at all times. Exosomes are a class of
extracellular vesicles released by all cells, with a size range of 40–150 nm and a lipid …

Exosomes and their roles in immune regulation and cancer

DW Greening, SK Gopal, R Xu, RJ Simpson… - Seminars in cell & …, 2015 - Elsevier
Exosomes, a subset of extracellular vesicles (EVs), function as a mode of intercellular
communication and molecular transfer. Exosomes facilitate the direct extracellular transfer of …

Exosome secretion: molecular mechanisms and roles in immune responses

A Bobrie, M Colombo, G Raposo, C Théry - Traffic, 2011 - Wiley Online Library
Exosomes are small membrane vesicles, secreted by most cell types from multivesicular
endosomes, and thought to play important roles in intercellular communications. Initially …

[HTML][HTML] Small extracellular vesicles in cancer

K Abhange, A Makler, Y Wen, N Ramnauth, W Mao… - Bioactive Materials, 2021 - Elsevier
Extracellular vesicles (EV) are lipid-bilayer enclosed vesicles in submicron size that are
released from cells. A variety of molecules, including proteins, DNA fragments, RNAs, lipids …

[HTML][HTML] Exosomes: secreted vesicles and intercellular communications

C Théry - F1000 biology reports, 2011 - ncbi.nlm.nih.gov
Exosomes are small membrane vesicles of endocytic origin secreted by most cell types, and
are thought to play important roles in intercellular communications. Although exosomes …

The biodistribution and immune suppressive effects of breast cancer–derived exosomes

SW Wen, J Sceneay, LG Lima, CSF Wong, M Becker… - Cancer research, 2016 - AACR
Small membranous secretions from tumor cells, termed exosomes, contribute significantly to
intercellular communication and subsequent reprogramming of the tumor microenvironment …

Therapy resistance mediated by exosomes

TB Steinbichler, J Dudás, S Skvortsov, U Ganswindt… - Molecular cancer, 2019 - Springer
Therapy resistance can arise within tumor cells because of genetic or phenotypic changes
(intrinsic resistance), or it can be the result of an interaction with the tumor microenvironment …

[HTML][HTML] Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human …

S Ye, ZL Li, D Luo, B Huang, YS Chen, X Zhang, J Cui… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Tumor-derived exosomes contain biologically active proteins and messenger and
microRNAs (miRNAs). These particles serve as vehicles of intercellular communication and …

Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumour-derived exosomes)

TL Whiteside - Biochemical Society Transactions, 2013 - portlandpress.com
Body fluids of cancer patients contain TEXs (tumour-derived exosomes). Tumours release
large quantities of TEXs, and the protein content of exosome or MV (microvesicle) fractions …

Prostate Tumor-Derived Exosomes Down-Regulate NKG2D Expression on Natural Killer Cells and CD8+ T Cells: Mechanism of Immune Evasion

M Lundholm, M Schröder, O Nagaeva, V Baranov… - PloS one, 2014 - journals.plos.org
Tumor-derived exosomes, which are nanometer-sized extracellular vesicles of endosomal
origin, have emerged as promoters of tumor immune evasion but their role in prostate …