Quinolizidine alkaloids, as essential active ingredients extracted from Sophora
alopecuroides Linn, have been well concerned in the past several decades owing to the …

Lung macrophages (Mφs) are essential for pulmonary innate immunity and host defense
due to their dynamic polarization and phenotype shifts. Mesenchymal stromal cells (MSCs) …

Previous studies demonstrated an important role of oxidative stress in the pathogenesis of
cardiovascular disease (CVD) in diabetic patients due to hyperglycemia. CVD remains the …

Acute lung injury (ALI) is an acute hypoxic respiratory insufficiency caused by various intra‐
and extrapulmonary injury factors. Presently, excessive inflammation in the lung and the …

The coronavirus disease 2019 (COVID-19) pandemic continues to burden healthcare
systems worldwide. COVID-19 symptoms are highly heterogeneous, and the patient may be …

Background/Aims: Acute lung injury (ALI) is induced by a variety of external and internal
factors and leads to acute progressive respiratory failure. Previous studies have shown that …

Acute respiratory disease syndrome (ARDS) is a common critical disease with high
morbidity and mortality rates, yet specific and effective treatments for it are currently lacking …

Background Airway instillation of bleomycin (BLM) in mice is a widely used, yet challenging,
model for acute lung injury (ALI) with high variability in treatment scheme and animal …

Ethnopharmacological relevance Yupingfengsan (YPFS) is a traditional Chinese medicine
decoction. YPFS comprises Astragalus mongholicus Bunge (Huangqi), Atractylodes rubra …

Rationale Alveolar epithelial cell death, inflammation, and oxidative stress are typical
features of acute lung injury (ALI). Aloperine (Alo), an alkaloid isolated from Sophora …