Reactive Oxygen Species-Triggered Curcumin Release from Hollow Mesoporous Silica Nanoparticles for PM2.5-Induced Acute Lung Injury Treatment

G Sun, X Wu, H Zhu, K Yuan, Y Zhang… - … Applied Materials & …, 2023 - ACS Publications
Exposure to fine particulate matter with a diameter≤ 2.5 μm (PM2. 5) can result in serious
inflammation and oxidative stress in lung tissue. However, there is presently very few …

Involvement of oxidative stress and the innate immune system in SARS-CoV-2 infection

EM Kozlov, E Ivanova, AV Grechko, WK Wu… - Diseases, 2021 - mdpi.com
The emergence of the novel coronavirus in December 2019 in China marked the beginning
of a pandemic that impacted healthcare systems and economic life all over the world. The …

The suppressive effects of Mer inhibition on inflammatory responses in the pathogenesis of LPS-induced ALI/ARDS

M Fukatsu, H Ohkawara, X Wang, L Alkebsi… - Science …, 2022 - science.org
The pathogenesis of sepsis-induced acute lung injury (ALI)/acute respiratory distress
syndrome (ARDS) has not yet been fully elucidated. Growth arrest–specific 6 (Gas6) has …

Apelin-13 attenuates lipopolysaccharide-induced inflammatory responses and acute lung injury by regulating PFKFB3-driven glycolysis induced by NOX4-dependent …

Y Yuan, W Wang, Y Zhang, Q Hong… - Journal of …, 2022 - Taylor & Francis
Purpose Acute lung injury (ALI) is a life-threatening condition with limited therapeutic
options. Macrophage inflammation plays a key role in the development of ALI. Abnormal …

Signaling pathways and potential therapeutic targets in acute respiratory distress syndrome (ARDS)

Q Huang, Y Le, S Li, Y Bian - Respiratory Research, 2024 - Springer
Acute respiratory distress syndrome (ARDS) is a common condition associated with critically
ill patients, characterized by bilateral chest radiographical opacities with refractory …

Oxidative stress mechanisms in the pathogenesis of environmental lung diseases

RK Thimmulappa, I Chattopadhyay… - Oxidative Stress in Lung …, 2020 - Springer
Globally, respiratory diseases are major cause of disability and mortality, and more
alarmingly, it disproportionately affects developing countries, which is largely attributed to …

Apelin-13, a regulator of autophagy, apoptosis and inflammation in multifaceted bone protection

G Gong, W Wan, X Liu, J Yin - International Immunopharmacology, 2023 - Elsevier
Apelin/APJ is widely distributed in various tissues in the body and participates in the
regulation of physiological and pathological mechanisms such as autophagy, apoptosis …

Diacerein attenuate LPS-induced acute lung injury via inhibiting ER stress and apoptosis: Impact on the crosstalk between SphK1/S1P, TLR4/NFκB/STAT3, and …

NS Youssef, AS Elzaitony, NAA Baky - Life Sciences, 2022 - Elsevier
Aims Acute lung injury (ALI) is a life-threatening clinical problem with high mortality rate and
limited treatments or preventive options that represents a major challenge for clinicians …

G6PD deficiency, redox homeostasis, and viral infections: implications for SARS-CoV-2 (COVID-19)

HC Yang, TH Ma, WY Tjong, A Stern… - Free radical …, 2021 - Taylor & Francis
The COVID-19 pandemic has so far affected more than 45 million people and has caused
over 1 million deaths worldwide. Infection with SARS-CoV-2, the pathogenic agent, which is …

Protective Effects of Atractylodis lancea Rhizoma on Lipopolysaccharide-Induced Acute Lung Injury via TLR4/NF-κB and Keap1/Nrf2 Signaling Pathways In Vitro and …

K Shi, Y Xiao, Y Dong, D Wang, Y Xie, J Tu… - International Journal of …, 2022 - mdpi.com
Acute lung injury (ALI) is a syndrome caused by an excessive inflammatory response
characterized by intractable hypoxemia both inside and outside the lung, for which effective …