Transforming growth factor-β (TGF-β) regulates many aspects of cellular function. A member
of the mitogen-activated protein kinase kinase kinase (MAPKKK) family, TAK1, was …

Extracellular‐signal‐regulated kinase 5 (ERK5) is a member of the mitogen‐activated
protein kinase (MAPK) family and, similar to ERK1/2, has the Thr–Glu–Tyr (TEY) activation …

The extracellular signal-regulated kinase (ERK) plays a central role in the signaling
cascades of cell growth. Here, we show that stochastic ERK activity pulses regulate cell …

Regulator of G protein signaling (RGS) proteins are responsible for the rapid turnoff of G
protein–coupled receptor signaling pathways. The major mechanism whereby RGS proteins …

The receptor activator of NF-κB ligand (RANKL) induces osteoclast differentiation from bone
marrow cells in the presence of macrophage colony-stimulating factor. We found that …

Many growth factors whose receptors are protein tyrosine kinases stimulate the MAP kinase
pathway by activating first the GTP‐binding protein Ras and then the protein kinase p74raf …

Although the involvement of protein kinase C (PKC) in the activation of the mitogen-activated
protein (MAP) kinase pathway has been implicated through experiments using 12-O …

Extracellular signal-regulated kinase 5 (ERK5), also termed big mitogen-activated protein
kinase-1 (BMK1), is the most recently identified member of the mitogen-activated protein …

The Raf family of protein kinases display differences in their abilities to promote the entry of
quiescent NIH 3T3 cells into the S phase of the cell cycle. Although conditional activation of …

The 90 kDa heat shock proteins (Hsp90), which are integrally involved in cell signaling,
proliferation, and survival, are ubiquitously expressed in cells. Many proteins in tumor cells …