We describe here the cloning and characterization of a cDNA encoding a protein kinase that
has high sequence homology to members of the mitogen-activated protein kinase (MAPK) …

The intracellular signalling field is dominated by the mitogen-activated protein kinase
(MAPK) cascade and its control, which involves the small GTPase Ras and sequential …

To elucidate the hidden dynamics of extracellular-signal-regulated kinase (ERK) signalling
networks, we developed a simulation model of ERK signalling networks by constraining in …

MAP kinases in eukaryotic cells are well known for transducing a variety of extracellular
signals to regulate cell growth and differentiation. Recently, MAP kinases homologous to the …

To comprehend the Ras/ERK MAPK cascade, which comprises Ras, Raf, MEK, and ERK,
several kinetic simulation models have been developed. However, a large number of …

Salt tolerance of crops could be improved by genetic engineering if basic questions on
mechanisms of salt toxicity and defense responses could be solved at the molecular level …

ERK5 (also known as BMK1), a member of the mitogen-activated protein kinase (MAPK)
superfamily, was known to be activated strongly by oxidant and osmotic stresses. Here we …

The HOG signal pathway of the yeast Saccharomyces cerevisiae is defined by the PBS2 and
HOG1 genes encoding members of the MAP kinase kinase and of the MAP kinase family …

IN fission yeast the onset of mitosis is brought about by Cdc2/Cdcl3 kinase, which is
inhibited by the Weel/Mikl tyrosine kin-ases and activated by Cdc25 tyrosine phosphatase1 …

MAP kinase phosphatases (MKPs) catalyze dephosphorylation of activated MAP kinase
(MAPK) molecules and deactivate them. Therefore, MKPs play an important role in …