Being the most common musculoskeletal progressive condition, osteoarthritis is an
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …

Osteoarthritis (OA), the commonest arthritis, is characterized by the progressive destruction
of cartilage, leading to disability. The Current early clinical treatment strategy for OA often …

Compromised autophagy and mitochondrial dysfunction downregulate chondrocytic activity,
accelerating the development of osteoarthritis (OA). Irisin, a cleaved form of fibronectin type …

Objective Obesity was once considered a risk factor for knee osteoarthritis (OA) primarily for
biomechanical reasons. Here we provide an additional perspective by discussing how …

Osteoarthritis (OA) is the leading cause of function loss and disability among the elderly, with
significant burden on the individual and society. It is a severe disease for its high disability …

The mechanistic target of rapamycin (mTOR) is a master regulator of the inflammatory
response in immune and non-immune cells. In immune cells mTOR regulates metabolism to …

Osteoarthritis is the most common musculoskeletal progressive disease, with the knee as
the most commonly affected joint in the human body. While several new medications are still …

Osteoarthritis (OA) is a progressive degenerative disease characterized by cartilage
degradation, synovial inflammation, subchondral sclerosis and osteophyte formation. It has …

Disorders of the synovial joint, such as osteoarthritis (OA) and rheumatoid arthritis (RA),
afflict a substantial proportion of the global population. However, current clinical …

Irisin, a myokine secreted by muscle during physical exercise, is known to have biological
activities in different cell types. Chondrocyte inflammation and pyroptosis have been shown …