Background According to the current need of manufacturing healthier products, food
companies are seeking specific biomolecules that may offer additional added value (ie …

Overcoming refractory epilepsy's resistance to the combination of antiepileptic drugs (AED),
mitigating side effects, and preventing sudden unexpected death in epilepsy are critical …

TRPV1 is a nonselective cation channel vital for detecting noxious stimuli (heat, acid,
capsaicin). Its role in pain makes it a potential drug target for chronic pain management …

Transient receptor potential vanilloid member 1 (TRPV1) is activated in response to
capsaicin, protons, temperature, and free reactive oxygen species (ROS) released from …

Based on the abundance of scientific publications, the polymodal sensor TRPV1 is known
as one of the most studied proteins within the TRP channel family. This receptor has been …

Highlights•Sensory perception needs to be considered in texture-modified food.•Food
design should consider sensory inputs for pleasant eating experiences.•Chemosensory …

The upper airway (nasal passages, paranasal sinuses, pharynx, and glottis) provides the
sentinel portion of the human respiratory tract, with the combined senses of olfaction (cranial …

We describe an in silico-guided rational drug design and the synthesis of the suggested
ligands, aimed at improving the TRPV1-ligand binding properties and the potency of N-(4 …

Several studies have documented the broad-spectrum bioactivities of a lotus seed (Plumula
nelumbinis [PN]) green embryo extract. However, the specific bioactive components and …

Background: In traditional Mongolian or Tibetan medicine in China, Chebulae Fructus (CF)
is widely used to process or combine with aconitums to decrease the severe toxicity of …