Natural killer cell homing and trafficking in tissues and tumors: from biology to application
GH Ran, YQ Lin, L Tian, T Zhang, DM Yan… - Signal transduction and …, 2022 - nature.com
Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary …
against cancer. Although some evidence shows that NK cells can develop in secondary …
[HTML][HTML] Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages
D Chen, X Zhang, Z Li, B Zhu - Theranostics, 2021 - ncbi.nlm.nih.gov
Macrophages phagocytize pathogens to initiate innate immunity and products from the
tumor microenvironment (TME) to mediate tumor immunity. The loss of tumor-associated …
tumor microenvironment (TME) to mediate tumor immunity. The loss of tumor-associated …
Chimeric antigen receptor-engineered NK-92 cells: an off-the-shelf cellular therapeutic for targeted elimination of cancer cells and induction of protective antitumor …
C Zhang, P Oberoi, S Oelsner, A Waldmann… - Frontiers in …, 2017 - frontiersin.org
Significant progress has been made in recent years toward realizing the potential of natural
killer (NK) cells for cancer immunotherapy. NK cells can respond rapidly to transformed and …
killer (NK) cells for cancer immunotherapy. NK cells can respond rapidly to transformed and …
Effect of tumor cells and tumor microenvironment on NK‐cell function
The ability of tumors to manage an immune‐mediated attack has been recently included in
the “next generation” of cancer hallmarks. In solid tumors, the microenvironment that is …
the “next generation” of cancer hallmarks. In solid tumors, the microenvironment that is …
CXCR4 and anti-BCMA CAR co-modified natural killer cells suppress multiple myeloma progression in a xenograft mouse model
The highly restricted expression of B-cell maturation antigen (BCMA) on plasma cells makes
it an ideal target for chimeric antigen receptor (CAR) immune cell therapy against multiple …
it an ideal target for chimeric antigen receptor (CAR) immune cell therapy against multiple …
Exercise-dependent regulation of NK cells in cancer protection
M Idorn, P Hojman - Trends in molecular medicine, 2016 - cell.com
Natural killer (NK) cells are the most responsive immune cells to exercise, displaying an
acute mobilization to the circulation during physical exertion. Recently, exercise-dependent …
acute mobilization to the circulation during physical exertion. Recently, exercise-dependent …
Gene regulatory programs conferring phenotypic identities to human NK cells
PL Collins, M Cella, SI Porter, S Li, GL Gurewitz… - Cell, 2019 - cell.com
Natural killer (NK) cells develop from common progenitors but diverge into distinct subsets,
which differ in cytokine production, cytotoxicity, homing, and memory traits. Given their …
which differ in cytokine production, cytotoxicity, homing, and memory traits. Given their …
Towards an integrative approach to understanding the role of chemerin in human health and disease
Chemerin is an adipocyte‐secreted protein with autocrine/paracrine roles on adipose
development and function as well as endocrine roles in metabolism and immunity. Following …
development and function as well as endocrine roles in metabolism and immunity. Following …
Tricking the balance: NK cells in anti-cancer immunity
J Pahl, A Cerwenka - Immunobiology, 2017 - Elsevier
Natural Killer (NK) cells are classically considered innate immune effector cells involved in
the first line of defense against infected and malignant cells. More recently, NK cells have …
the first line of defense against infected and malignant cells. More recently, NK cells have …
NK cells in the tumor microenvironment
C Guillerey - Tumor Microenvironment: Hematopoietic Cells–Part B, 2020 - Springer
Natural killer cells are powerful effectors of innate immunity that constitute a first line of
defense against cancer. NK cells express an array of germline-encoded receptors which …
defense against cancer. NK cells express an array of germline-encoded receptors which …