Natural killer cell homing and trafficking in tissues and tumors: from biology to application

GH Ran, YQ Lin, L Tian, T Zhang, DM Yan… - Signal transduction and …, 2022 - nature.com
Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary …

[HTML][HTML] Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages

D Chen, X Zhang, Z Li, B Zhu - Theranostics, 2021 - ncbi.nlm.nih.gov
Macrophages phagocytize pathogens to initiate innate immunity and products from the
tumor microenvironment (TME) to mediate tumor immunity. The loss of tumor-associated …

Chimeric antigen receptor-engineered NK-92 cells: an off-the-shelf cellular therapeutic for targeted elimination of cancer cells and induction of protective antitumor …

C Zhang, P Oberoi, S Oelsner, A Waldmann… - Frontiers in …, 2017 - frontiersin.org
Significant progress has been made in recent years toward realizing the potential of natural
killer (NK) cells for cancer immunotherapy. NK cells can respond rapidly to transformed and …

Effect of tumor cells and tumor microenvironment on NK‐cell function

M Vitale, C Cantoni, G Pietra… - European journal of …, 2014 - Wiley Online Library
The ability of tumors to manage an immune‐mediated attack has been recently included in
the “next generation” of cancer hallmarks. In solid tumors, the microenvironment that is …

CXCR4 and anti-BCMA CAR co-modified natural killer cells suppress multiple myeloma progression in a xenograft mouse model

YY Ng, Z Du, X Zhang, WJ Chng, S Wang - Cancer Gene Therapy, 2022 - nature.com
The highly restricted expression of B-cell maturation antigen (BCMA) on plasma cells makes
it an ideal target for chimeric antigen receptor (CAR) immune cell therapy against multiple …

Exercise-dependent regulation of NK cells in cancer protection

M Idorn, P Hojman - Trends in molecular medicine, 2016 - cell.com
Natural killer (NK) cells are the most responsive immune cells to exercise, displaying an
acute mobilization to the circulation during physical exertion. Recently, exercise-dependent …

Gene regulatory programs conferring phenotypic identities to human NK cells

PL Collins, M Cella, SI Porter, S Li, GL Gurewitz… - Cell, 2019 - cell.com
Natural killer (NK) cells develop from common progenitors but diverge into distinct subsets,
which differ in cytokine production, cytotoxicity, homing, and memory traits. Given their …

Towards an integrative approach to understanding the role of chemerin in human health and disease

JL Rourke, HJ Dranse, CJ Sinal - Obesity Reviews, 2013 - Wiley Online Library
Chemerin is an adipocyte‐secreted protein with autocrine/paracrine roles on adipose
development and function as well as endocrine roles in metabolism and immunity. Following …

Tricking the balance: NK cells in anti-cancer immunity

J Pahl, A Cerwenka - Immunobiology, 2017 - Elsevier
Natural Killer (NK) cells are classically considered innate immune effector cells involved in
the first line of defense against infected and malignant cells. More recently, NK cells have …

NK cells in the tumor microenvironment

C Guillerey - Tumor Microenvironment: Hematopoietic Cells–Part B, 2020 - Springer
Natural killer cells are powerful effectors of innate immunity that constitute a first line of
defense against cancer. NK cells express an array of germline-encoded receptors which …