Immunotherapies in chronic pain through modulation of neuroimmune interactions

J Zhao, Y Huh, A Bortsov, L Diatchenko… - Pharmacology & …, 2023 - Elsevier
It is generally believed that immune activation can elicit pain through production of
inflammatory mediators that can activate nociceptive sensory neurons. Emerging evidence …

PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior

J Zhao, S Bang, K Furutani, A McGinnis, C Jiang… - Neuron, 2023 - cell.com
Summary Programmed death protein 1 (PD-1) and its ligand PD-L1 constitute an immune
checkpoint pathway. We report that neuronal PD-1 signaling regulates learning/memory in …

PD-L1/PD-1 pathway: a potential neuroimmune target for pain relief

D Deng, T Zhang, L Ma, W Zhao, S Huang, K Wang… - Cell & Bioscience, 2024 - Springer
Pain is a common symptom of many diseases with a high incidence rate. Clinically, drug
treatment, as the main method to relieve pain at present, is often accompanied by different …