Aspergillus, a genus of filamentous fungi, is extensively distributed in nature and plays
crucial roles in the decomposition of organic materials as an important environmental …

Triazole antifungals function as ergosterol biosynthesis inhibitors and are frontline therapy
for invasive fungal infections, such as invasive aspergillosis. The primary mechanism of …

Aspergillus fumigatus is a ubiquitous environmental mold that can cause severe disease in
immunocompromised patients and chronic disease in individuals with underlying lung …

Purpose The objective of this study was to determine the clinical distribution, in vitro
antifungal susceptibility and underlying resistance mechanisms of Aspergillus fumigatus (A …

Azole resistance in Aspergillus fumigatus is a worldwide concern and new antifungal drugs
are required to overcome this problem. Statin, a 3-hydroxy-3-methylglutaryl-coenzyme A …

Aspergillus fumigatus is a pathogenic fungus with a global distribution. The emergence of
azole-resistant A. fumigatus (AR Af) other than the TR-mutants is a problem in Japan …

Fungal infections are increasingly dangerous because of environmentally dispersed
resistance to antifungal drugs. Azoles are commonly used antifungal drugs, but they are also …

Aspergillus fumigatus is a common causative pathogen of aspergillosis. At present, triazole
resistance of A. fumigatus poses an important challenge to human health globally. In this …

Invasive aspergillosis, mainly caused by Aspergillus fumigatus, can lead to severe clinical
outcomes in immunocompromised individuals. Antifungal treatment, based on the use of …

Triazole resistance in the pathogenic mold Aspergillus fumigatus has increased worldwide,
posing a growing therapeutic challenge. Recently, mutations in the 3-hydroxy-3-methyl …