By virtue of their large number, widespread distribution and important roles in cell
physiology and biochemistry, G-protein-coupled receptors (GPCR) play multiple important …

Allosteric receptor ligands bind to a recognition site that is distinct from the binding site of the
endogenous messenger molecule. As a consequence, allosteric agents may attach to …

A straightforward process for the N-alkylation of amines has been developed applying
readily available carboxylic acids and silanes as the hydride source. Complementary to …

Celebrating more than twenty years as the single best source in the field, this Fifth Edition
has now expanded into two cornerstone volumes with 53 fully inclusive chapters and 73 …

The calcium-sensing receptor (CaR), a member of G protein-coupled receptor family C,
regulates systemic calcium homeostasis by activating G q-and G i-linked signaling in the …

The current interest of the scientific community for research in the field of calcium sensing in
general and on the calcium-sensing Receptor (CaR) in particular is demonstrated by the still …

Direct alkylation of a methyl group, on di‐and trisubstituted ureas, with terminal alkenes by C
(sp3)− H bond activation proceeded in the presence of a hydroxoiridium/bisphosphine …

The design, synthesis and calcimimetic properties of various cyclic sulfonamides and
sulfamates are described. The latter were prepared from the corresponding o …

The calcium sensing receptor (CaR) is a G protein-coupled receptor (GPCR) that plays a
fundamental role in serum calcium homeostasis. The CaR is expressed on the chief cells of …

Calcimimetics and vitamin D sterols reduce serum parathyroid hormone (PTH) in patients
with secondary hyperparathyroidism receiving dialysis, a disease state associated with …