Trematodes cause disease in millions of people worldwide, but the absence of commercial
vaccines has led to an over-reliance on a handful of monotherapies to control infections …

Diseases caused by parasitic flatworms impart a considerable healthcare burden worldwide.
Many of these diseases—for example, the parasitic blood fluke infection schistosomiasis …

Genomic resources for Platyhelminthes of the class Monogenea are scarce, despite the
diversity of these parasites, some species of which are highly pathogenic to their fish hosts …

Introduction Praziquantel (PZQ), an anthelmintic drug discovered in the 1970s, is still used to
treat schistosomiasis and various other infections caused by parasitic flatworms. PZQ …

Fasciola spp. liver flukes have significant impacts in veterinary and human medicine. The
absence of a vaccine and increasing anthelmintic resistance threaten sustainable control …

Long non-coding (lnc) RNAs are a class of eukaryotic RNA that do not code for protein and
are linked with transcriptional regulation, amongst a myriad of other functions. Using a …

Glycoproteins secreted by helminth parasites are immunogenic and represent appealing
components of vaccine preparations. Our poor knowledge of the pathways that mediate …

The liver fluke, Fasciola hepatica, is a global burden on the wellbeing and productivity of
farmed ruminants, and a zoonotic threat to human health. Despite the clear need for …

Tetraspanins are a superfamily of transmembrane proteins that in flatworms have structural
roles in the development, maturation or stability of the tegument. Several tetraspanins are …

The tegument is the layer in most intimate contact with the host's tissues and body fluids. As
such, it represents a site where considerable biochemical, physiological and immune …