Frontotemporal lobar degeneration (FTLD) is a clinically and pathologically heterogeneous
syndrome, characterized by progressive decline in behaviour or language associated with …

Drosophila melanogaster has been utilized to model human brain diseases. In most of these
invertebrate transgenic models, some aspects of human disease are reproduced. Although …

Through undefined mechanisms, dominant mutations in (Cu/Zn) superoxide dismutase‐1
(mSOD1) cause the non‐cell‐autonomous death of motoneurons in inherited amyotrophic …

Toll‐like receptors (TLRs) are known to be expressed by innate immune response cells and
to play a critical role in their activation against foreign pathogens. It was recently suggested …

Mutations in the DNA/RNA binding proteins TDP-43 and FUS are associated with
Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration. Intracellular …

Background aims Amyotrophic lateral sclerosis (ALS) is characterized by the selective death
of motor neurons. CD133+ stem cells are known to have the capacity to differentiate into …

ALS is now understood to be a complex multisystem neurodegenerative disease because
areas other than the motor cortices of the brain undergo degeneration. Frontotemporal …

Extracellular vesicles (EVs), including exosomes, microvesicles and apoptotic bodies,
participate in intercellular communication, and particularly, in paracrine and endocrine …

Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease. It is
typically characterized by adult-onset degeneration of the upper and lower motor neurons …

Objective: To define the temporal evolution of intrinsic tissue damage and atrophy in the
cervical cord and the brain portion of the corticospinal tracts (CST) from patients with …