PI3K/Akt signaling in osteosarcoma
Osteosarcoma (OS) is the most common nonhematologic bone malignancy in children and
adolescents. Despite the advances of adjuvant chemotherapy and significant improvement …
adolescents. Despite the advances of adjuvant chemotherapy and significant improvement …
[HTML][HTML] The disruption of protein− protein interactions with co-chaperones and client substrates as a strategy towards Hsp90 inhibition
MA Serwetnyk, BSJ Blagg - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Abstract The 90-kiloDalton (kD) heat shock protein (Hsp90) is a ubiquitous, ATP-dependent
molecular chaperone whose primary function is to ensure the proper folding of several …
molecular chaperone whose primary function is to ensure the proper folding of several …
Anticancer mechanisms and clinical application of alkylphospholipids
WJ van Blitterswijk, M Verheij - … et Biophysica Acta (BBA)-Molecular and …, 2013 - Elsevier
Synthetic alkylphospholipids (ALPs), such as edelfosine, miltefosine, perifosine,
erucylphosphocholine and erufosine, represent a relatively new class of structurally related …
erucylphosphocholine and erufosine, represent a relatively new class of structurally related …
The roles of glycolysis in osteosarcoma
Z Feng, Y Ou, L Hao - Frontiers in Pharmacology, 2022 - frontiersin.org
Metabolic reprogramming is of great significance in the progression of various cancers and
is critical for cancer progression, diagnosis, and treatment. Cellular metabolic pathways …
is critical for cancer progression, diagnosis, and treatment. Cellular metabolic pathways …
Targeting Akt/PKB in pediatric tumors: A review from preclinical to clinical trials
The serine/threonine kinase Akt is a major player in the phosphoinositide 3-kinase
(PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway, and its modulation …
(PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway, and its modulation …
[HTML][HTML] mTOR signaling in osteosarcoma: Oncogenesis and therapeutic aspects
K Hu, HB Dai, ZL Qiu - Oncology reports, 2016 - spandidos-publications.com
The mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase that
belongs to the phosphoinositide-3-kinase (PI3K)-related kinase family. Oncogenic activation …
belongs to the phosphoinositide-3-kinase (PI3K)-related kinase family. Oncogenic activation …
Alkyl ether lipids, ion channels and lipid raft reorganization in cancer therapy
PA Jaffres, C Gajate, AM Bouchet… - Pharmacology & …, 2016 - Elsevier
Synthetic alkyl lipids, such as the ether lipids edelfosine (1-O-octadecyl-2-O-methyl-rac-
glycero-3-phosphocholine) and ohmline (1-O-hexadecyl-2-O-methyl-rac-glycero-3-β …
glycero-3-phosphocholine) and ohmline (1-O-hexadecyl-2-O-methyl-rac-glycero-3-β …
Molecular chaperones in osteosarcoma: diagnosis and therapeutic issues
M Lallier, L Marchandet, B Moukengue, C Charrier… - Cells, 2021 - mdpi.com
Osteosarcoma (OS) is the most common form of primary bone tumor affecting mainly
children and young adults. Despite therapeutic progress, the 5-year survival rate is 70%, but …
children and young adults. Despite therapeutic progress, the 5-year survival rate is 70%, but …
[HTML][HTML] mTOR: An attractive therapeutic target for osteosarcoma?
L Ding, L Congwei, Q Bei, Y Tao, W Ruiguo, Y Heze… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Osteosarcoma (OS) is a common primary malignant bone tumor with high morbidity and
mortality in children and young adults. How to improve poor prognosis of OS due to …
mortality in children and young adults. How to improve poor prognosis of OS due to …
Doxorubicin and edelfosine lipid nanoparticles are effective acting synergistically against drug-resistant osteosarcoma cancer cells
Y González-Fernández, E Imbuluzqueta, M Zalacain… - Cancer letters, 2017 - Elsevier
Despite the great advances that have been made in osteosarcoma therapy during recent
decades, recurrence and metastases are still the most common outcome of the primary …
decades, recurrence and metastases are still the most common outcome of the primary …