Growth hormone (GH) deficiency (GHD) in children is defined as impaired production of GH
by the pituitary gland that results in growth failure. This disease might be congenital or …

Normal hypothalamopituitary development is closely related to that of the forebrain and is
dependent upon a complex genetic cascade of transcription factors and signaling molecules …

Precise control of transcriptional programmes underlying metazoan development is
modulated by enzymatically active co-regulatory complexes, coupled with epigenetic …

The pituitary gland adapts the proportion of each of its endocrine cell types to meet differing
hormonal demands throughout life. There is circumstantial evidence that multipotent adult …

The transcription factor SOX2 is expressed most notably in the developing CNS and
placodes, where it plays critical roles in embryogenesis. Heterozygous de novo mutations in …

The pituitary gland is a central endocrine organ regulating basic physiological functions,
including growth, the stress response, reproduction, metabolic homeostasis, and lactation …

Dwarf mice are remarkably long-lived. Congenital deficiency of growth hormone (GH),
prolactin, and thyroid-stimulating hormone (TSH) due to mutations at the Pit1 or Prop1 loci …

Living organisms represent, in essence, dynamic interactions of high complexity between
membrane‐separated compartments that cannot exist on their own, but reach behaviour in …

Significant progress has been made recently in unravelling the embryonic events leading to
pituitary morphogenesis, both in vivo and in vitro. This includes dissection of the molecular …

A side population (SP) has been identified in a number of tissues, where it typically
represents a small population enriched in stem/progenitor cells. In this study we show that …