Background The adult endocrine pituitary is known to host several hormone-producing cells
regulating major physiological processes during life. Some candidates to progenitor/stem …

Defects in pituitary gland organogenesis are sometimes associated with congenital
anomalies that affect head development. Lesions in transcription factors and signaling …

Mammalian organogenesis results from the concerted actions of signaling pathways in
progenitor cells that induce a hierarchy of regulated transcription factors critical for organ …

Obesity is an escalating epidemic, but an effective noninvasive therapy is still scarce. For
obesity treatment, anorexigenic neuropeptides are promising tools, but their delivery from …

Many aspects of pituitary development have become better understood in the past two
decades. The signaling pathways regulating pituitary growth and shape have emerged, and …

Septo-optic dysplasia (SOD) is a highly heterogeneous condition comprising variable
phenotypes including midline and forebrain abnormalities, optic nerve and pituitary …

The development of the anterior pituitary gland occurs in distinct sequential developmental
steps, leading to the formation of a complex organ containing five different cell types …

The anterior pituitary gland has the ability to respond to complex signals derived from central
and peripheral systems. Perception of these signals and their integration are mediated by …

Recent advances in tridimensional (3D) tissue imaging have considerably enriched our view
of the pituitary gland and its development. Whereas traditional histology of the pituitary …

Patterning and differentiation signals are often believed to drive the developmental program,
including cell cycle exit of proliferating progenitors. Taking advantage of the spatial and …