Abstract The Cancer Stem Cells (CSCs) theory suggests that genetic alterations in stem
cells are the direct cause for cancer. The evidence for a CSC population that results in …

Pituitary gonadotrope cells are essential for the endocrine regulation of reproduction in
vertebrates. These cells emerge early during embryogenesis, colonize the pituitary glands …

The recent demonstration using genetic tracing that in the adult pituitary stem cells are
normally recruited from the niche in the marginal zone and differentiate into secretory cells in …

Sox2 mutations are associated with pituitary hormone deficiencies and the protein is
required for pituitary progenitor proliferation, but its function has not been well characterized …

Multiple signaling molecules and transcription factors are required for pituitary development.
Activator-type bHLH genes Mash1, Math, NeuroD (Neurod) and Neurogenin (Neurog) are …

The anterior pituitary gland is comprised of specialized cell-types that produce and secrete
polypeptide hormones in response to hypothalamic input and feedback from target organs …

Objective Homozygous mutations in the gene encoding the pituitary transcription factor
PROP1 are associated with combined pituitary hormone deficiency (CPHD) in both mice …

The adrenal glands are important endocrine organs that play a major role in the stress
response. Some adrenal glands abnormalities are treated with hormone replacement …

The most commonly identified genetic cause of combined pituitary hormone deficiency
(CPHD) is PROP1 gene mutations. The aim of the study was to compare selected clinical …

The pituitary gland represents the organism's endocrine hub, integrating central and
peripheral inputs to generate the appropriate hormonal signals that govern key …