Purinergic signaling triggers endfoot high-amplitude Ca2+ signals and causes inversion of neurovascular coupling after subarachnoid hemorrhage

AC Pappas, M Koide… - Journal of Cerebral Blood …, 2016 - journals.sagepub.com
Neurovascular coupling supports brain metabolism by matching focal increases in neuronal
activity with local arteriolar dilation. Previously, we demonstrated that an emergence of …

Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2

S Martínez-Torres, L Cutando, A Pastor, A Kato… - Brain, Behavior, and …, 2019 - Elsevier
Monoacylglycerol lipase (MAGL) is the main enzyme implicated in the degradation of the
most abundant endocannabinoid in the brain, 2-arachidonoylglycerol (2-AG), producing …

Pharmacological tools to activate microglia and their possible use to study neural network patho-physiology

F Peña-Ortega - Current neuropharmacology, 2017 - ingentaconnect.com
Background: Microglia are the resident immunocompetent cells of the CNS and also
constitute a unique cell type that contributes to neural network homeostasis and function …

Modulation of P2Y11-related purinergic signaling in inflammation and cardio-metabolic diseases

MD Dănilă, M Piollet, OM Aburel, D Angoulvant… - European Journal of …, 2020 - Elsevier
Chronic inflammation is the hallmark of cardiovascular pathologies with a major role in both
disease progression and occurrence of long-term complications. The massive release of …

Celecoxib alleviates oxaliplatin-induced hyperalgesia through inhibition of spinal ERK1/2 signaling

H Chen, Q Wang, D Shi, D Yao, L Zhang… - Journal of toxicologic …, 2016 - jstage.jst.go.jp
Numerous pieces of evidence have revealed that oxaliplatin (OXA) evokes mechanical and
cold hypersensitivity. However, the mechanism underlying these bothersome side effects …

[HTML][HTML] Inhibition of Monoacylglycerol Lipase by NSD1819 as an Effective Strategy for the Endocannabinoid System Modulation against Neuroinflammation-Related …

L Micheli, S Maramai, A Toti, V Ferrara… - International Journal of …, 2022 - mdpi.com
Neuroinflammation is a key pathological event shared by different diseases affecting the
nervous system. Since the underlying mechanism of neuroinflammation is a complex and …

The role of P2Y6 receptors in the maintenance of neuropathic pain and its improvement of oxidative stress in rats

Z Wang, WS Zhao, XY Shen, HF Wan… - Journal of cellular …, 2019 - Wiley Online Library
Aim To explore the role of P2Y6 receptors in the maintenance of neuropathic pain and
progression of oxidative stress, we investigated the efficacy of the selective P2Y6 receptors …

[HTML][HTML] P2RY6 在非小细胞肺癌中的表达和临床意义分析

周永生, 熊延路, 冯杨波, 乔天运, 赵晋波, 雷杰, 姜涛… - 中国肿瘤临床, 2020 - cjco.cn
P2RY6在非小细胞肺癌中的表达和临床意义分析 首页 期刊简介 1.期刊介绍 2.获奖情况 编委会
期刊在线 1.最新录用 2.优先发表 3.当期目录 4.过刊浏览 视频合辑 在线投稿 1.投稿须知 2.稿约 …

P2Y11 receptor antagonist NF340 ameliorates inflammation in human fibroblast‐like synoviocytes: an implication in rheumatoid arthritis

F Gao, X Li - IUBMB life, 2019 - Wiley Online Library
Rheumatoid arthritis is a common chronic inflammatory joint disease. Fibroblast‐like
synoviocytes‐mediated inflammation is closely associated with the development of …

[HTML][HTML] Efficacy of a vegetal mixture composed of Zingiber officinale, Echinacea purpurea, and Centella asiatica in a mouse model of neuroinflammation: In vivo and …

L Micheli, A Toti, E Lucarini, V Ferrara, C Ciampi… - Frontiers in …, 2022 - frontiersin.org
Experimental evidence suggests that neuroinflammation is a key pathological event of many
diseases affecting the nervous system. It has been well recognized that these devastating …