[HTML][HTML] Anti-Biofilm Effects of Rationally Designed Peptides against Planktonic Cells and Pre-Formed Biofilm of Pseudomonas aeruginosa

YM Kim, H Son, SC Park, JK Lee, MK Jang, JR Lee - Antibiotics, 2023 - mdpi.com
Biofilms are resistant to antibiotics and are a major source of persistent and recurring
infections by clinically important pathogens. Drugs used for biofilm-associated infections are …

Deciphering the structure and mechanism of action of computer‐designed mastoparan peptides

KGN Oshiro, CDP Freitas, SB Rezende… - The FEBS …, 2024 - Wiley Online Library
Mastoparans are cationic peptides with multifunctional pharmacological properties.
Mastoparan‐R1 and mastoparan‐R4 were computationally designed based on native …

[HTML][HTML] Potent Antifungal Functions of a Living Modified Organism Protein, CP4-EPSPS, against Pathogenic Fungal Cells

SC Park, HS Lim, SE Mun, YJ Jung, AM Yoon, H Son… - Molecules, 2023 - mdpi.com
Various proteins introduced into living modified organism (LMO) crops function in plant
defense mechanisms against target insect pests or herbicides. This study analyzed the …

Narrow spectrum nano-antibiotic for selective removal of ARB from contaminated water: New insights into stimuli response based on cellular attachment, lysis, and …

A Raichur, N Sinha - Journal of Hazardous Materials, 2024 - Elsevier
Narrow spectrum nano-antibiotics are supposedly the future trouble-shooters to improve the
efficacy of conventional antimicrobials for treatment of severe bacterial infections, remove …

Microscopic and metabolomics analysis of the anti-Listeria activity of natural and engineered cruzioseptins

S Bermúdez-Puga, M Dias, IL Reis, TF de Oliveira… - Biochimie, 2024 - Elsevier
Listeria monocytogenes is a human opportunistic foodborne pathogen that produces life-
threatening infections with a high mortality rate. The control of Listeria in the food production …

Effect of tryptophan position and lysine/arginine substitution in antimicrobial peptides on antifungal action

YM Kim, SC Park, Y Yoon, MK Jang, JR Lee - Biochemical and Biophysical …, 2024 - Elsevier
Every year, the overprescription, misuse, and improper disposal of antibiotics have led to the
rampant development of drug-resistant pathogens and, in turn, a significant increase in the …

[HTML][HTML] Effect of central PxxP motif in amphipathic alpha-helical peptides on antimicrobial activity and mode of action

H Lee, S Yang, SH Shin - Journal of Analytical Science and Technology, 2023 - Springer
Amphipathic α-helical peptides (AHPs) have shown potential as a therapeutic approach
against multi-drug-resistant bacterial infections due to their broad-spectrum antimicrobial …

Effects of structural changes on antibacterial activity and cytotoxicity due to proline substitutions in chimeric peptide HnMc

SC Park, JK Lee, YM Kim, JR Lee - Biochemical and Biophysical Research …, 2023 - Elsevier
Owing to the rapidly increasing emergence of multidrug-resistant pathogens, antimicrobial
peptides (AMPs) are being explored as next-generation antibiotics. However, AMPs present …

Soluble Expression of Antimicrobial Peptide BSN-37 from Escherichia coli by SUMO Fusion Technology

Y Xu, M Dong, Q Wang, Y Sun, B Hang, H Zhang… - The Protein …, 2023 - Springer
Antimicrobial peptides (AMPs) are a kind of small molecular peptide that an organism
produces to resist the invasion of foreign microorganisms. AMP BSN-37 is a bovine AMP …

基于生物信息学改造天然抗菌肽的研究.

宋雪莹, 高圣玥, 李平, 宋岩, 赵金波, 李莉… - Feed …, 2024 - search.ebscohost.com
抗菌肽(AMPs) 是一种小分子多肽, 具有广谱抗菌, 抗病毒, 抗寄生虫, 抗肿瘤细胞的作用,
可促进动物生长发育, 提高生产性能. 因此, 在替抗背景下, AMPs 有望成为新型绿色“抗生素” …