Malaria is the fifth most lethal parasitic infection in the world. Antimalarial medications have
played a crucial role in preventing and eradicating malaria. Numerous heterocyclic moieties …

In recent times, the novel concept of generating hybrid molecules by pharmacophoric
hybridisation approach is fast becoming an alternative to other existing strategies of drug …

The pharmacogenetics of antimalarial agents are poorly known, although the application of
pharmacogenetics might be critical in optimizing treatment. This population pharmacokinetic …

Objectives To estimate caretaker adherence to co‐blistered, but not co‐formulated,
artesunate‐amodiaquine (AsAq) for uncomplicated malaria and identify factors associated …

Pharmacogenomics are frequently considered in personalized medicine to maximize
therapeutic benefits and minimize adverse drug reactions. However, there is a movement …

Introduction: Plasmodium falciparum malaria is one of the world's most lethal infectious
diseases, commanding millions of drug administrations per year. The pharmacogenetics of …

Background CYP2C8 is responsible for the metabolism of 5% of clinically prescribed drugs,
including antimalarials, anti-cancer and anti-inflammatory drugs. Genetic variability is an …

Antimicrobial efficacy and toxicity varies between individuals owing to multiple factors.
Genetic variants that affect drug-metabolizing enzymes may influence antimicrobial …

Our knowledge of the biological mechanisms underlying complex human disease is largely
incomplete. While Semantic Web technologies, such as the Web Ontology Language (OWL) …

The present monograph reviews data relevant to applying the biowaiver procedure for the
approval of immediate release (IR) multisource solid dosage forms containing amodiaquine …