Regulatory T cells (Tregs) characterized by the expression of the master transcription factor
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …

The proper restraint of the destructive potential of the immune system is essential for
maintaining health. Regulatory T (Treg) cells ensure immune homeostasis through their …

T regulatory cells suppress a variety of immune responses to self-antigens and play a role in
peripheral tolerance maintenance by limiting autoimmune disorders, and other pathological …

The distinction between innate and adaptive immunity is one of the basic tenets of
immunology. The co-operation between these two arms of the immune system is a major …

Multiple sclerosis (MS) has long been considered a CD4 T-cell disease, primarily because
of the findings that the strongest genetic risk for MS is the major histocompatibility complex …

Abstract Forkhead box P3 (FOXP3)+ regulatory T (TReg) cells are potent mediators of
dominant self tolerance in the periphery. But confusion as to the identity, stability and …

Immunological self tolerance is maintained at least in part by regulatory T (Treg) cells that
actively and dominantly control potentially hazardous self-reactive T cells in the periphery …

CD4+ T cells are commonly divided into regulatory T (Treg) cells and conventional T helper
(Th) cells. Th cells control adaptive immunity against pathogens and cancer by activating …

Chronic and acute renal diseases, irrespective of the initiating cause, have inflammation and
immune system activation as a common underlying mechanism. The purpose of this review …

Immune cells were traditionally considered as major pro-inflammatory contributors. Recent
advances in molecular immunology prove that immune cell lineages are composed of …