Lectins, a class of sugar-binding and cell-agglutinating proteins, are ubiquitous in Nature,
being found in all kinds of organisms, from viruses to humans. This review describes how …

Matrilysin, a matrix metalloproteinase, is expressed and secreted lumenally by intact
mucosal and glandular epithelia throughout the body, suggesting that its regulation and …

The majority of infectious diseases are initiated by adhesion of pathogenic organisms to the
tissues of the host. In many cases, this adhesion is mediated by lectins present on the …

Urinary tract infection (UTI) is among the most common infectious diseases of humans and is
the most common nosocomial infection in the developed world. They cause significant …

Gram-negative uropathogenic Escherichia coli (UPEC) bacteria are a causative pathogen of
urinary tract infections (UTIs). Previously developed antivirulence inhibitors of the type 1 …

Herein, we describe the X-ray structure-based design and optimization of biaryl mannoside
FimH inhibitors. Diverse modifications to the biaryl ring to improve druglike physical and …

Management of bacterial infections is becoming increasingly difficult due to the emergence
and increasing prevalence of bacterial pathogens that are resistant to available antibiotics …

Pentaerythritol and bis‐pentaerythritol scaffolds were used for the preparation of first
generation glycodendrimers bearing aryl α‐d‐mannopyranoside residues assembled using …

Adhesion is a prerequisite for bacteria to colonize cell surfaces. To accomplish cellular
adhesion, many bacteria use carbohydrate‐specific lectins, which are expressed as part of …

ABSTRACT Introduction: The bacterial adhesin FimH is a virulence factor and an attractive
therapeutic target for urinary tract infection (UTI) and Crohn's Disease (CD). Located on type …