Personalized whole-brain neural mass models reveal combined Aβ and tau hyperexcitable influences in Alzheimer's disease
Neuronal dysfunction and cognitive deterioration in Alzheimer's disease (AD) are likely
caused by multiple pathophysiological factors. However, mechanistic evidence in humans …
caused by multiple pathophysiological factors. However, mechanistic evidence in humans …
Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer's pathology
Dysfunction in fast-spiking parvalbumin interneurons (PV-INs) may represent an early
pathophysiological perturbation in Alzheimer's Disease (AD). Defining early proteomic …
pathophysiological perturbation in Alzheimer's Disease (AD). Defining early proteomic …
Associations between regional blood-brain barrier permeability, aging, and Alzheimer's disease biomarkers in cognitively normal older adults
M Denkinger, S Baker, B Inglis, S Kobayashi, A Juarez… - Plos one, 2024 - journals.plos.org
Background Increased blood-brain barrier permeability (BBBp) has been hypothesized as a
feature of aging that may lead to the development of Alzheimer's disease (AD). We sought to …
feature of aging that may lead to the development of Alzheimer's disease (AD). We sought to …
Meta-Analysis in Transgenic Alzheimer's Disease Mouse Models Reveals Opposite Brain Network Effects of Amyloid-β and Phosphorylated Tau Proteins
CA García-Carlos, G Basurto-Islas… - Journal of …, 2024 - content.iospress.com
Background: Cognitive deficits observed in Alzheimer's disease (AD) patients have been
correlated with altered hippocampal activity. Although the mechanism remains under …
correlated with altered hippocampal activity. Although the mechanism remains under …
[HTML][HTML] Adenosine deficiency facilitates CA1 synaptic hyperexcitability in the presymptomatic phase of a knock in mouse model of Alzheimer's disease
The disease's trajectory of Alzheimer's disease (AD) is associated with and worsened by
hippocampal hyperexcitability. Here we show that during the asymptomatic stage in a knock …
hippocampal hyperexcitability. Here we show that during the asymptomatic stage in a knock …
Tau pathology leads to lonely non-traveling slow waves that mediate human memory impairment
Memory markedly declines with age, exaggerated in those with Alzheimer's disease, yet the
mechanisms are still not resolved. Here, we show that frontal lobe tau pathology in humans …
mechanisms are still not resolved. Here, we show that frontal lobe tau pathology in humans …
Autoimmune antibody-induced neuronal hyperactivity triggers pathological Tau in IgLON5 disease
B Askin, C Cordero Gomez, SLL Duong, C Kilic… - bioRxiv, 2024 - biorxiv.org
Anti-IgLON5 disease is an autoimmunity/neurodegeneration overlap disorder in which
autoantibodies (AABs) against the neuronal cell surface protein IgLON5 lead to profound …
autoantibodies (AABs) against the neuronal cell surface protein IgLON5 lead to profound …
Digital cognitive assessments as low-burden markers for predicting future cognitive decline and tau accumulation across the Alzheimer's spectrum
CR Vanderlip, CEL Stark - bioRxiv, 2024 - biorxiv.org
Digital cognitive assessments, particularly those that can be done at home, present as low
burden biomarkers for participants and patients alike, but their effectiveness in diagnosis of …
burden biomarkers for participants and patients alike, but their effectiveness in diagnosis of …
Medial amygdalar tau is associated with anxiety symptoms in preclinical Alzheimer's disease
BACKGROUND: While the amygdala receives early tau deposition in Alzheimer's disease
(AD) and is involved in social and emotional processing, the relationship between …
(AD) and is involved in social and emotional processing, the relationship between …
Drosophila appear resistant to trans-synaptic tau propagation
JH Catterson, EN Mouofo, I Lopez De Toledo Soler… - bioRxiv, 2024 - biorxiv.org
Alzheimers disease (AD) is the most common cause of dementia in the elderly, prompting
extensive efforts to pinpoint novel therapeutic targets for effective intervention. Among the …
extensive efforts to pinpoint novel therapeutic targets for effective intervention. Among the …