Adenosine, acting both through G-protein coupled adenosine receptors and intracellularly,
plays a complex role in multiple physiological and pathophysiological processes by …

The bi‐directional relationship between sleep and stress has been actively researched as
sleep disturbances and stress have become increasingly common in society. Interestingly …

The human Subthalamic Nucleus (STh) is a diencephalic lens-shaped structure located
ventrally to the thalamus and functionally implicated in the basal ganglia circuits. Despite …

It is well known that astrocytes play a significant metabolic role in the nervous tissue,
maintaining the homeostasis of the extracellular space and of the blood-brain barrier, and …

In the last decades, new evidence on brain structure and function has been acquired by
morphological investigations based on synergic interactions between biochemical anatomy …

Adenosine and dopamine interact antagonistically in living mammals. These interactions are
mediated via adenosine A2A and dopamine D2 receptors (R). Stimulation of A2AR inhibits …

We present a brief historical and epistemological outline of investigations on the brain's
structure and functions. These investigations have mainly been based on the intermingling …

Dopamine neurotransmission plays critical roles in regulating complex cognitive and
behavioral processes including reward, motivation, reinforcement learning, and movement …

A critical aspect of drug development in the therapy of neuropsychiatric diseases is the
“Target Problem”, that is, the selection of a proper target after not simply the etiopathological …

The discovery that receptors from all families can establish allosteric receptor–receptor
interactions and variably associate to form receptor complexes operating as integrative input …