Angiogenesis is an essential process in normal development and in adult physiology, but
can be disrupted in numerous diseases. The concept of targeting angiogenesis for treating …

Simple Summary An overwhelming percentage of deaths in solid tumors are caused by
treatment failure due to the disease's unresponsiveness when tumor cells tolerate treatment …

Inflammatory molecules and exosomes are crucial for signal transduction between tumor-
associated macrophages and tumor cells. IL-6, a key inflammatory molecule secreted by M2 …

Background Non-small cell lung carcinoma (NSCLC) is a type lung cancer with high
malignant behaviors. MicroRNAs (miRNAs) are known to be involved in progression of …

Circular RNAs (circRNAs) are a new series of noncoding RNAs (ncRNAs) that have been
reported to be expressed in eukaryotic cells and have a variety of biological functions in the …

Background Gastric cancer (GC) is one of the most lethal malignant tumors worldwide with
poor outcomes. Vascular mimicry (VM) is an alternative blood supply to tumors that is …

Tumour progression and metastasis remain the leading causes of cancer-related death
worldwide. Tumour angiogenesis is essential for tumour progression. The vasculature …

Simple Summary The glycocalyx is a fluffy sugar coat covering the surface of all mammalian
cells. While glycocalyx at endothelial cells is a barrier to tumor cell adhesion and …

Sphingosine 1-phosphate (S1P) is a bioactive metabolite of sphingomyelin. S1P activates a
series of signaling cascades by acting on its receptors S1PR1-3 on endothelial cells (ECs) …

Glioma is a devastating cancer with a rich vascular network. No anti-angiogenic treatment is
available for prolonging the overall survival of glioma patients. Recent studies have …