Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor …
CR Elcombe, RC Peffer, DC Wolf, J Bailey… - Critical reviews in …, 2014 - Taylor & Francis
The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are important
nuclear receptors involved in the regulation of cellular responses from exposure to many …
nuclear receptors involved in the regulation of cellular responses from exposure to many …
Mechanisms of liver disease: cross-talk between the NF-κB and JNK pathways
The liver plays a central role in the transformation and degradation of endogenous and
exogenous chemicals, and in the removal of unwanted cells such as damaged, genetically …
exogenous chemicals, and in the removal of unwanted cells such as damaged, genetically …
[图书][B] Environmental chemistry
SE Manahan - 2022 - taylorfrancis.com
With clear explanations, real-world examples and updated ancillary material, the 11th
edition of Environmental Chemistry emphasizes the concepts essential to the practice of …
edition of Environmental Chemistry emphasizes the concepts essential to the practice of …
Induction of drug metabolism: species differences and toxicological relevance
MJ Graham, BG Lake - Toxicology, 2008 - Elsevier
A large number of drugs and other chemicals have been shown to induce hepatic
microsomal cytochrome P450 (CYP) forms in experimental animals and humans. Most CYP …
microsomal cytochrome P450 (CYP) forms in experimental animals and humans. Most CYP …
CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of ω-3-polyunsaturated fatty acids, and functional deficit of the p. H331P variant
M Nakano, EJ Kelly, C Wiek, H Hanenberg… - Molecular …, 2012 - ASPET
Bietti's crystalline corneoretinal dystrophy (BCD) is a recessive degenerative eye disease
caused by germline mutations in the CYP4V2 gene. More than 80% of mutant alleles consist …
caused by germline mutations in the CYP4V2 gene. More than 80% of mutant alleles consist …
Expression and characterization of CYP4V2 as a fatty acid ω-hydroxylase
Bietti's crystalline dystrophy is an ocular disease that is strongly associated with
polymorphisms in the CYP4V2 gene. CYP4 enzymes are typically microsomal fatty acid ω …
polymorphisms in the CYP4V2 gene. CYP4 enzymes are typically microsomal fatty acid ω …
Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators
BG Lake - Toxicology research, 2018 - academic.oup.com
A large number of nongenotoxic chemicals have been shown to increase the incidence of
liver tumours in rats and/or mice by a mode of action (MOA) involving activation of the …
liver tumours in rats and/or mice by a mode of action (MOA) involving activation of the …
Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model
X Zhou, X Zhuo, F Xie, K Kluetzman, YZ Shu… - … of Pharmacology and …, 2010 - ASPET
CYP2A5, a mouse cytochrome P450 monooxygenase that shows high similarities to human
CYP2A6 and CYP2A13 in protein sequence and substrate specificity, is expressed in …
CYP2A6 and CYP2A13 in protein sequence and substrate specificity, is expressed in …
Spirocyclic Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-3-hydroxy-4-(spiro[chromene-2,4′-piperidine]-4-yl) Benzamide …
B Le Bourdonnec, RT Windh, LK Leister… - Journal of medicinal …, 2009 - ACS Publications
Selective, nonpeptidic δ opioid receptor agonists have been the subject of great interest as
potential novel analgesic agents. The discoveries of BW373U86 (1) and SNC80 (2) …
potential novel analgesic agents. The discoveries of BW373U86 (1) and SNC80 (2) …
Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour formation
BG Lake - Xenobiotica, 2009 - Taylor & Francis
Phenobarbitone and related compounds induce hepatic microsomal cytochrome P450
(CYP) 2B forms (mediated by the constitutive androstane receptor), whereas peroxisome …
(CYP) 2B forms (mediated by the constitutive androstane receptor), whereas peroxisome …