Pathogens penetrating the central nervous system: infection pathways and the cellular and molecular mechanisms of invasion
The brain is well protected against microbial invasion by cellular barriers, such as the blood-
brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB). In addition, cells …
brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB). In addition, cells …
Current and new generation pneumococcal vaccines
C Feldman, R Anderson - Journal of Infection, 2014 - Elsevier
Pneumococcal polysaccharide vaccines (PPVs) and conjugate vaccines (PCVs), of which
PPV23 and PCV13 are the current front runners, have had a significant, beneficial impact on …
PPV23 and PCV13 are the current front runners, have had a significant, beneficial impact on …
[HTML][HTML] Role of Streptococcus pneumoniae Proteins in Evasion of Complement-Mediated Immunity
GO Andre, TR Converso, WR Politano… - Frontiers in …, 2017 - frontiersin.org
The complement system plays a central role in immune defense against Streptococcus
pneumoniae. In order to evade complement attack, pneumococci have evolved a number of …
pneumoniae. In order to evade complement attack, pneumococci have evolved a number of …
[HTML][HTML] A nanogel-based trivalent PspA nasal vaccine protects macaques from intratracheal challenge with pneumococci
R Nakahashi-Ouchida, Y Uchida, Y Yuki, Y Katakai… - Vaccine, 2021 - Elsevier
Current polysaccharide-based pneumococcal vaccines are effective but not compatible with
all serotypes of Streptococcus pneumoniae. We previously developed an adjuvant-free …
all serotypes of Streptococcus pneumoniae. We previously developed an adjuvant-free …
[HTML][HTML] Novel protein-based pneumococcal vaccines: assessing the use of distinct protein fragments instead of full-length proteins as vaccine antigens
T Lagousi, P Basdeki, J Routsias, V Spoulou - Vaccines, 2019 - mdpi.com
Non-serotype-specific protein-based pneumococcal vaccines have received extensive
research focus due to the limitations of polysaccharide-based vaccines. Pneumococcal …
research focus due to the limitations of polysaccharide-based vaccines. Pneumococcal …
Pneumococcal surface protein A inhibits complement deposition on the pneumococcal surface by competing with the binding of C-reactive protein to cell-surface …
In the presence of normal serum, complement component C3 is deposited on pneumococci
primarily via the classical pathway. Pneumococcal surface protein A (PspA), a major …
primarily via the classical pathway. Pneumococcal surface protein A (PspA), a major …
Current status and perspectives on protein-based pneumococcal vaccines
Despite the efforts to expand the availability of conjugate vaccines, pneumococcal diseases
still pose an enormous burden worldwide. Therefore, several proteins have been …
still pose an enormous burden worldwide. Therefore, several proteins have been …
[HTML][HTML] Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae
HM Jindal, CF Le, MY Mohd Yusof, RD Velayuthan… - PloS one, 2015 - journals.plos.org
Antimicrobial peptides (AMPs) represent promising alternatives to conventional antibiotics in
order to defeat multidrug-resistant bacteria such as Streptococcus pneumoniae. In this study …
order to defeat multidrug-resistant bacteria such as Streptococcus pneumoniae. In this study …
[HTML][HTML] Peptide linker increased the stability of pneumococcal fusion protein vaccine candidate
L Zane, S Kraschowetz, MM Trentini… - … in Bioengineering and …, 2023 - frontiersin.org
Streptococcus pneumoniae is a bacterial pathogen exclusive to humans, responsible for
respiratory and systemic diseases. Pneumococcal protein vaccines have been proposed as …
respiratory and systemic diseases. Pneumococcal protein vaccines have been proposed as …
[HTML][HTML] Diverse mechanisms of protective anti-pneumococcal antibodies
AD Gingerich, JJ Mousa - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
The gram-positive bacterium Streptococcus pneumoniae is a leading cause of pneumonia,
otitis media, septicemia, and meningitis in children and adults. Current prevention and …
otitis media, septicemia, and meningitis in children and adults. Current prevention and …