Beta cell dysfunction and insulin resistance are inherently complex with their interrelation for
triggering the pathogenesis of diabetes also somewhat undefined. Both pathogenic states …

Although β-cell heterogeneity was discovered more than 50 years ago, the underlying
principles have been explored only during the past decade. Islet-cell heterogeneity arises …

Pancreatic islets are richly vascularized, and islet blood vessels are uniquely adapted to
maintain and support the internal milieu of the islets favoring normal endocrine function. Islet …

Type 1 diabetes (T1DM) affects one in every 400 children and adolescents in the US. Due to
the limitations of exogenous insulin therapy and whole pancreas transplantation, pancreatic …

Pancreatic β-cells perform glucose-stimulated insulin secretion, a process at the center of
type 2 diabetes etiology. Efforts to understand how β-cells behave in healthy and stressful …

The human genome project and its search for factors underlying human diseases has
fostered a major human research effort. Therefore, unsurprisingly, in recent years we have …

Context: Bariatric surgery leads to a rapid and sustained weight loss often accompanied with
improvement in glucose homeostasis. Objective: The objective of this study was to …

Glucose homeostasis greatly depends on the match between fluctuating insulin demands
and adjusted rates of insulin secretion, which is the function of pancreatic beta cells …

Mouse models of Streptozotocin (STZ) induced diabetes represent the most widely used
preclinical diabetes research systems. We applied state of the art optical imaging schemes …

Aims Beta cells adapt to an increased insulin demand by enhancing insulin secretion via
increased beta cell function and/or increased beta cell number. While morphological and …