The diversity, composition, and function of the bacterial community inhabiting the human
gastrointestinal tract contributes to host health through its role in producing energy or …

The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …

Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …

Background & Aims Aldafermin, an engineered analog of fibroblast growth factor 19, inhibits
bile acid synthesis and regulates metabolic homeostasis. We report results from a 24-week …

Of all the novel glucoregulatory molecules discovered in the past 20 years, bile acids (BAs)
are notable for the fact that they were hiding in plain sight. BAs were well known for their …

Background Non-alcoholic steatohepatitis is a chronic liver disease characterised by the
presence of hepatic steatosis, inflammation, and hepatocellular injury, for which no Food …

Background Non-alcoholic steatohepatitis (NASH) is characterised by hepatic steatosis,
inflammation, and injury, and is associated with an increased risk of liver transplantation and …

Bile acids (BAs) are evolutionally conserved molecules synthesized in the liver from
cholesterol and have been shown to be essential for lipid homeostasis. BAs regulate a …

NGM282, an engineered fibroblast growth factor 19 analogue, rapidly and significantly
reduced liver fat content in a multicenter, randomized, double‐blind, placebo‐controlled …

Nonalcoholic fatty liver disease (NAFLD) is a spectrum of disease, extending from simple
steatosis to inflammation and fibrosis with a significant risk for the development of cirrhosis. It …