SIRT7: a novel molecular target for personalized cancer treatment?
The Sirtuin family of NAD+-dependent enzymes assumes a pivotal role in orchestrating
adaptive responses to environmental fluctuations and stress stimuli, operating at both …
adaptive responses to environmental fluctuations and stress stimuli, operating at both …
Sirtuins in kidney diseases: potential mechanism and therapeutic targets
Q Jin, F Ma, T Liu, L Yang, H Mao, Y Wang… - Cell Communication and …, 2024 - Springer
Sirtuins, which are NAD+-dependent class III histone deacetylases, are involved in various
biological processes, including DNA damage repair, immune inflammation, oxidative stress …
biological processes, including DNA damage repair, immune inflammation, oxidative stress …
Immune regulation and the tumor microenvironment in anti-PD-1/PDL-1 and anti-CTLA-4 therapies for cancer immune evasion: A bibliometric analysis
Y Huang, Z Chen, G Shen, S Fang… - Human Vaccines & …, 2024 - Taylor & Francis
This study aims to conduct a bibliometric analysis, employing visualization tools to examine
literature pertaining to tumor immune evasion related to anti-CTLA-4 and anti-PD-1/PD-L1 …
literature pertaining to tumor immune evasion related to anti-CTLA-4 and anti-PD-1/PD-L1 …
The dark side of SIRT7
FA Lagunas-Rangel - Molecular and Cellular Biochemistry, 2023 - Springer
Abstract Sirtuin 7 (SIRT7) is a member of the sirtuin family and has emerged as a key player
in numerous cellular processes. It exhibits various enzymatic activities and is predominantly …
in numerous cellular processes. It exhibits various enzymatic activities and is predominantly …
SIRT7 promotes Hippo/YAP activation and cancer cell proliferation in hepatocellular carcinoma via suppressing MST1
Y Gu, C Ding, T Yu, B Liu, W Tang, Z Wang… - Cancer …, 2024 - Wiley Online Library
Abnormal activation of the oncogene YAP in the Hippo pathway is a major feature in liver
cancer and inactivation of MST1/2 has been shown to be responsible for the overactivation …
cancer and inactivation of MST1/2 has been shown to be responsible for the overactivation …
Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing
L Zhao, J Chen, B Bai, G Song, J Zhang, H Yu… - Frontiers in …, 2024 - frontiersin.org
Topical drug delivery is widely used in various diseases because of the advantages of not
passing through the gastrointestinal tract, avoiding gastrointestinal irritation and hepatic first …
passing through the gastrointestinal tract, avoiding gastrointestinal irritation and hepatic first …
DDX3X interacts with SIRT7 to promote PD-L1 expression to facilitate PDAC progression
T Zhao, H Zhu, T Zou, S Zhao, L Zhou, M Ni, F Liu… - Oncogenesis, 2024 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is recognized as the most aggressive and fatal
malignancy. A previous study reported that PDAC patients who exhibit elevated levels of …
malignancy. A previous study reported that PDAC patients who exhibit elevated levels of …
BCKDHA contributes to melanoma progression by promoting the expressions of lipogenic enzymes FASN and ACLY
Y Tian, J Ma, M Wang, X Yi, S Guo… - Experimental …, 2023 - Wiley Online Library
The dysregulation of branched‐chain amino acid (BCAA) metabolism and related enzymes
has been greatly implicated in the progression of multiple types of cancer, whereas remains …
has been greatly implicated in the progression of multiple types of cancer, whereas remains …
Unraveling the multifaceted role of SIRT7 and its therapeutic potential in human diseases
H Li, Z Yuan, J Wu, J Lu, Y Wang, L Zhang - International Journal of …, 2024 - Elsevier
Sirtuins, as NAD+-dependent deacetylases, are widely found in eubacteria, archaea, and
eukaryotes, and they play key roles in regulating cellular functions. Among these, SIRT7 …
eukaryotes, and they play key roles in regulating cellular functions. Among these, SIRT7 …
Functional Diversity of SIRT7 Across Cellular Compartments: Insights and Perspectives
S Wu, S Jia - Cell Biochemistry and Biophysics, 2023 - Springer
Posttranslational modifications (PTMs) play important roles in the regulation of protein
function. Acetylation and deacetylation are among the most important PTMs. SIRT7 is a …
function. Acetylation and deacetylation are among the most important PTMs. SIRT7 is a …