Liquid–liquid phase separation (LLPS) of proteins underlies the formation of membrane-less
organelles. While it has been recognized for some time that these organelles are of key …

Frontotemporal lobar degeneration (FTLD) is one of the most common causes of early-onset
dementia and presents with early social–emotional–behavioural and/or language changes …

The nucleoplasm is not homogenous; it consists of many types of nuclear bodies, also
known as nuclear domains or nuclear subcompartments. These self-organizing structures …

The mechanisms by which mutations in FUS and other RNA binding proteins cause ALS
and FTD remain controversial. We propose a model in which low-complexity (LC) domains …

Pathological aggregation of the transactive response DNA-binding protein of 43 kDa (TDP-
43) is associated with several neurodegenerative disorders, including ALS, frontotemporal …

Traumatic brain injury (TBI) has long been recognized to be a risk factor for dementia. This
association has, however, only recently gained widespread attention through the increased …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
aggregation of ubiquitinated proteins in affected motor neurons. Recent studies have …

Amyotrophic lateral sclerosis and several other neurodegenerative diseases are associated
with brain deposits of amyloid-like aggregates formed by the C-terminal fragments of TDP …

The discovery that heterozygous and homozygous mutations in the gene encoding
progranulin are causally linked to frontotemporal dementia and lysosomal storage disease …

Abstract Development of therapeutics for genetically complex neurodegenerative diseases
such as sporadic amyotrophic lateral sclerosis (ALS) has largely been hampered by lack of …