Context Although polycystic ovary syndrome (PCOS) is the most common endocrinopathy
affecting women of reproductive age, risk factors that may cause the syndrome are poorly …

Despite tremendous progress in detecting DNA variants associated with human disease,
interpreting their functional impact in a high-throughput and single-base resolution manner …

Purpose Breast cancer is a major public health concern worldwide and shows significant
heterogeneity between male and female. Knowing the global incidence landscape in both …

Background Both depression and breast cancer (BC) contribute to a substantial global
burden of morbidity and mortality among women, and previous studies have observed a …

Background Previous studies have linked gut microbiota with cancer etiology, but the
associations for specific gut microbiota are causal or owing to bias remain to be elucidated …

Background Tumour necrosis factor (TNF) inhibitors are used in the treatment of certain
autoimmune diseases but given the role of TNF in tumour biology and atherosclerosis, such …

Abstract Polygenic Risk Scores (PRS) are a major component of accurate breast cancer risk
prediction and have the potential to improve screening and prevention strategies. PRS …

Observational studies have reported inconsistent associations between circulating lipids
and breast cancer risk. Using results from> 400,000 participants in two-sample Mendelian …

Low muscle strength is an important heritable indicator of poor health linked to morbidity and
mortality in older people. In a genome-wide association study meta-analysis of 256,523 …

Biomarkers for early detection of breast cancer may complement population screening
approaches to enable earlier and more precise treatment. The blood proteome is an …