Skeletal dysplasias are a diverse group of heritable diseases affecting bone and cartilage
growth. Throughout the years, the molecular defect underlying many of the diseases has …

Observational studies have reported inconsistent associations between circulating lipids
and breast cancer risk. Using results from> 400,000 participants in two-sample Mendelian …

Background Previous studies have linked gut microbiota with cancer etiology, but the
associations for specific gut microbiota are causal or owing to bias remain to be elucidated …

While many germline cancer risk variants have been identified through genome-wide
association studies (GWAS), the mechanisms by which these variants operate remain …

Background Epidemiological evidence supports a positive association between circulating
insulin-like growth factor-1 (IGF-1) concentrations and breast cancer risk, but both the …

Background Epidemiological studies have reported conflicting findings on the potential
adverse effects of long-term antihypertensive medication use on cancer risk. Naturally …

Understanding how natural selection has shaped genetic architecture of complex traits is of
importance in medical and evolutionary genetics. Bayesian methods have been developed …

Context Although polycystic ovary syndrome (PCOS) is the most common endocrinopathy
affecting women of reproductive age, risk factors that may cause the syndrome are poorly …

Introduction: Heritage is the most important risk factor for breast cancer. About 15–20% of
breast cancer is familial, referring to affected women who have one or more first-or second …

Background A number of epidemiological and genetic studies have attempted to determine
whether levels of circulating lipids are associated with risks of various cancers, including …