Breast cancer risk factors and their effects on survival: a Mendelian randomisation study
M Escala-Garcia, A Morra, S Canisius, J Chang-Claude… - BMC medicine, 2020 - Springer
Background Observational studies have investigated the association of risk factors with
breast cancer prognosis. However, the results have been conflicting and it has been …
breast cancer prognosis. However, the results have been conflicting and it has been …
Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study
M Vithayathil, P Carter, S Kar, AM Mason… - PLoS …, 2021 - journals.plos.org
Background Evidence for the impact of body size and composition on cancer risk is limited.
This mendelian randomisation (MR) study investigates evidence supporting causal …
This mendelian randomisation (MR) study investigates evidence supporting causal …
Insights into breast cancer in the east vs the west: a review
YS Yap, YS Lu, K Tamura, JE Lee, EY Ko… - JAMA …, 2019 - jamanetwork.com
Importance During the past few decades, the incidence of breast cancer (BC) has been
increasing rapidly in East Asia, and BC is currently the most common cancer in several …
increasing rapidly in East Asia, and BC is currently the most common cancer in several …
A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer
The breast cancer risk variants identified in genome-wide association studies explain only a
small fraction of the familial relative risk, and the genes responsible for these associations …
small fraction of the familial relative risk, and the genes responsible for these associations …
Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction
We performed genome-wide association studies of breast cancer including 18,034 cases
and 22,104 controls of African ancestry. Genetic variants at 12 loci were associated with …
and 22,104 controls of African ancestry. Genetic variants at 12 loci were associated with …
Causal relationship between genetically predicted depression and cancer risk: a two-sample bi-directional mendelian randomization
GL Zhu, C Xu, K Yang, SQ Tang, LL Tang, L Chen… - BMC cancer, 2022 - Springer
Background Depression has been reported to be associated with some types of cancer in
observational studies. However, the direction and magnitude of the causal relationships …
observational studies. However, the direction and magnitude of the causal relationships …
Strategies to investigate and mitigate collider bias in genetic and Mendelian randomisation studies of disease progression
Genetic studies of disease progression can be used to identify factors that may influence
survival or prognosis, which may differ from factors that influence on disease susceptibility …
survival or prognosis, which may differ from factors that influence on disease susceptibility …
Mendelian randomization analyses of 23 known and suspected risk factors and biomarkers for breast cancer overall and by molecular subtypes
Many risk factors have been identified for breast cancer. The potential causality for some of
them remains uncertain, and few studies have comprehensively investigated these …
them remains uncertain, and few studies have comprehensively investigated these …
CRISPR screens identify gene targets at breast cancer risk loci
Background Genome-wide association studies (GWAS) have identified> 200 loci associated
with breast cancer risk. The majority of candidate causal variants are in non-coding regions …
with breast cancer risk. The majority of candidate causal variants are in non-coding regions …
Identifying loci with different allele frequencies among cases of eight psychiatric disorders using CC-GWAS
WJ Peyrot, AL Price - Nature genetics, 2021 - nature.com
Psychiatric disorders are highly genetically correlated, but little research has been
conducted on the genetic differences between disorders. We developed a new method …
conducted on the genetic differences between disorders. We developed a new method …